INT125080

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 16.16
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
colon 4
telomere 2
T cells 2
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 11 99.98 Very High Very High Very High
narcan 2 99.82 Very High Very High Very High
cINOD 25 99.24 Very High Very High Very High
Osteoarthritis 45 96.00 Very High Very High Very High
cytokine 30 80.88 Quite High
Pain 5 79.96 Quite High
Cannabinoid receptor 1 79.36 Quite High
Inflammation 40 79.32 Quite High
agonist 9 78.04 Quite High
Glutamate 29 74.40 Quite High
Disease Link Frequency Relevance Heat
Cancer 612 100.00 Very High Very High Very High
Apoptosis 171 100.00 Very High Very High Very High
Endometrial Cancer 459 99.96 Very High Very High Very High
Hypoxia 7 99.74 Very High Very High Very High
Colon Cancer 45 98.68 Very High Very High Very High
Malignant Neoplastic Disease 68 97.80 Very High Very High Very High
Aging 35 97.72 Very High Very High Very High
Telangiectasia 17 97.60 Very High Very High Very High
INFLAMMATION 55 96.68 Very High Very High Very High
Disease 180 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that prodigiosin triggers accumulation of the DNA-damage response tumor-suppressor protein p53 but that NAG-1 induction was independent of p53 accumulation.
Neg (independent) Positive_regulation (independent) of Positive_regulation (accumulation) of p53 associated with cancer
1) Confidence 0.58 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17237295 Disease Relevance 0.67 Pain Relevance 0.09
Recent studies reported that mutation of p53 may contribute to the increased COX-2 expression that is observed in malignant tissues (18, 19).
Spec (may) Positive_regulation (contribute) of Positive_regulation (mutation) of p53 associated with malignant neoplastic disease
2) Confidence 0.46 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 1.36 Pain Relevance 0
DNA damage and hypoxia resulted in increased p53 protein accumulation indicating that PDF expression may be controlled by cellular levels of p53.
Positive_regulation (increased) of Positive_regulation (accumulation) of p53 associated with hypoxia
3) Confidence 0.45 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.87 Pain Relevance 0.23
In p53 positive endometrioid endometrial carcinoma, p53 protein accumulation may be secondary to changes in its upstream regulatory proteins rather than the p53 gene itself.
Positive_regulation (secondary) of Positive_regulation (accumulation) of p53 associated with endometrial cancer
4) Confidence 0.43 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.31 Pain Relevance 0
In p53 positive endometrioid endometrial carcinoma, p53 protein accumulation may be secondary to changes in its upstream regulatory proteins rather than the p53 gene itself.
Positive_regulation (secondary) of Positive_regulation (changes) of p53 associated with endometrial cancer
5) Confidence 0.43 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.29 Pain Relevance 0
Here, we show that treatment of the human colon carcinoma cell line HCT116 with different concentrations of R-flurbiprofen leads to an accumulation of p53 protein which is accompanied by an increase in phosphorylated p53 at serine 15.
Positive_regulation (leads) of Positive_regulation (accumulation) of p53 in colon associated with colon cancer
6) Confidence 0.42 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15710360 Disease Relevance 0.67 Pain Relevance 0.12
Alternatively, nonspecific DNA damage such as that induced by irradiation is also known to induce accumulation of wild-type p53 [12].
Positive_regulation (induce) of Positive_regulation (accumulation) of p53
7) Confidence 0.40 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.75 Pain Relevance 0
On the other hand, the induction of functional p53 induced by depsipeptide sensitizes SW-1736 cells to doxorubicin [60].
Positive_regulation (induction) of Positive_regulation (induced) of p53
8) Confidence 0.33 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762324 Disease Relevance 0.23 Pain Relevance 0
On the other hand, the induction of functional p53 induced by depsipeptide sensitizes SW-1736 cells to doxorubicin [60].
Positive_regulation (induced) of Positive_regulation (induction) of p53
9) Confidence 0.33 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762324 Disease Relevance 0.23 Pain Relevance 0
Present data indicate that UVB radiation caused DNA damage and p53 activation in HCE cells.
Positive_regulation (caused) of Positive_regulation (activation) of p53
10) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.72 Pain Relevance 0
RESULTS: We show that p53 and damage-specific DNA binding protein 2 (ddb2) genes are up-regulated by morphine in a naloxone-sensitive manner.
Positive_regulation (up) of Positive_regulation (regulated) of p53
11) Confidence 0.29 Published 2009 Journal Biochim. Biophys. Acta Section Body Doc Link 19397953 Disease Relevance 0 Pain Relevance 0
Morphine induces DNA damage and P53 activation in CD3+ T cells.
Positive_regulation (induces) of Positive_regulation (activation) of P53 in T cells associated with morphine
12) Confidence 0.29 Published 2009 Journal Biochim. Biophys. Acta Section Title Doc Link 19397953 Disease Relevance 0 Pain Relevance 0.43
Sulindac sulfide induced expression of p21wafl/cipl in a dose-dependent fashion, decreased cyclin D1 protein levels, and increased Rb hypophosphorylation. p21waf1/cip1 protein levels increased without a significant increase in wild-type p53, suggesting that sulindac sulfide induces a p53-independent pathway regulating p2lwafl/ciP1 protein levels in SCCHN.
Positive_regulation (increased) of Neg (without) Positive_regulation (increase) of p53
13) Confidence 0.28 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 17172818 Disease Relevance 0.37 Pain Relevance 0.07
Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells.
Positive_regulation (mediated) of Positive_regulation (Induction) of p53 in colon associated with colon cancer, cinod and apoptosis
14) Confidence 0.24 Published 2010 Journal Biochem. Pharmacol. Section Title Doc Link 20230799 Disease Relevance 0.70 Pain Relevance 0.33
By chemical fractionation, the activity was assigned to its constituent Withanone (i-Factor) that was shown to cause activation of tumor suppressor protein p53 in cancer cells only [8], [9].
Positive_regulation (cause) of Positive_regulation (activation) of tumor suppressor protein p53 associated with cancer
15) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958829 Disease Relevance 0.80 Pain Relevance 0.10
-galactosidase activity [12], increase in reactive oxygen species (ROS), telomere attrition [13] and p53/p16ink4 accumulation [11].
Positive_regulation (increase) of Positive_regulation (accumulation) of p53 in telomere
16) Confidence 0.13 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.61 Pain Relevance 0.38
can induce apoptosis in MEFs, which is enhanced by loss of p53, suggesting a potential role for p53 in regulating apoptosis upon CK1?
Positive_regulation (potential) of Positive_regulation (role) of p53 associated with apoptosis
17) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.82 Pain Relevance 0
Tamagno’s group have also published results that demonstrate recruitment of p53 and cytosolic release of cytochrome-c as well as activation of caspase-3 (all excellent markers of apoptosis), in A?
Positive_regulation (demonstrate) of Positive_regulation (recruitment) of p53 associated with apoptosis
18) Confidence 0.08 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 1.11 Pain Relevance 0.03
In addition, we see no variation in exon 6, which contains the substrate binding domain necessary for p53 activation.
Positive_regulation (necessary) of Positive_regulation (activation) of p53
19) Confidence 0.08 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.67 Pain Relevance 0
Induction of p53 leads to a reduction of Tcf4 mRNA and protein [166], and thus acts to decrease the Wnt/?
Positive_regulation (leads) of Positive_regulation (Induction) of p53
20) Confidence 0.07 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.52 Pain Relevance 0

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