INT125081

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.20
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
colon 2
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 79.32 Quite High
Inflammation 2 78.84 Quite High
cytokine 1 55.96 Quite High
Potency 2 27.04 Quite Low
dexamethasone 10 9.32 Low Low
peripheral neuropathy 13 5.00 Very Low Very Low Very Low
Duloxetine 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Gabapentin 1 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 2 98.44 Very High Very High Very High
Death 1 96.04 Very High Very High Very High
Apoptosis 17 94.08 High High
Hypoxia 1 80.72 Quite High
Cancer 14 80.68 Quite High
INFLAMMATION 2 78.84 Quite High
Adhesions 2 75.28 Quite High
Stress 1 71.12 Quite High
Skin Cancer 1 21.04 Low Low
Mantle-cell Lymphoma 1 20.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that treatment of the human colon carcinoma cell line HCT116 with different concentrations of R-flurbiprofen leads to an accumulation of p53 protein which is accompanied by an increase in phosphorylated p53 at serine 15.
Positive_regulation (accumulation) of p53 Binding (accompanied) of in colon associated with colon cancer
1) Confidence 0.46 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15710360 Disease Relevance 0.67 Pain Relevance 0.12
Indeed, more recent studies suggest the antimyeloma activity of proteasome inhibition is actually p53 independent.71
Positive_regulation (actually) of p53 Binding (independent.71) of
2) Confidence 0.12 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

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