INT125089

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.09

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plasma membrane (HLA-B, TDGF1) cell differentiation (TDGF1) extracellular space (TDGF1)
Golgi apparatus (TDGF1) nucleus (TDGF1) embryo development (TDGF1)
HLA-B (Homo sapiens)
TDGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 1 90.24 High High
Disease Link Frequency Relevance Heat
Low Back Pain 1 90.24 High High
Autoimmune Disease 1 89.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As peptide presentation by HLA molecules is of central importance for immune responses, we performed thermodynamic (circular dichroism, differential scanning calorimetry, fluorescence polarization) and X-ray crystallographic analyses of both HLA-B27 subtypes complexed with the epidermal growth factor response factor 1-derived self-peptide TIS (RRLPIFSRL) to understand the impact of the Asp116His exchange on peptide display.
HLA-B27 Spec (analyses) Binding (complexed) of epidermal growth factor response factor 1-derived
1) Confidence 0.24 Published 2005 Journal J. Mol. Biol. Section Abstract Doc Link 15713487 Disease Relevance 0.18 Pain Relevance 0.09

General Comments

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