INT125101

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 16.54
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP9) peptidase activity (CASP9) nucleus (CASP9)
intracellular (CASP9)
Anatomy Link Frequency
cleavage 2
LoVo 2
B-cell 1
BxPC-3 1
lung 1
CASP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 33 85.52 High High
antagonist 48 85.28 High High
cINOD 44 57.20 Quite High
Inflammation 29 50.00 Quite Low
lidocaine 4 50.00 Quite Low
cytokine 24 27.88 Quite Low
COX-2 inhibitor 7 25.36 Quite Low
agonist 56 5.00 Very Low Very Low Very Low
palliative 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 9 99.52 Very High Very High Very High
Apoptosis 1161 99.40 Very High Very High Very High
Cancer 431 99.38 Very High Very High Very High
Death 174 99.12 Very High Very High Very High
Shock 9 98.96 Very High Very High Very High
Lung Cancer 25 98.12 Very High Very High Very High
Pancreatic Cancer 63 96.48 Very High Very High Very High
Injury 33 95.04 Very High Very High Very High
Chordoma 131 92.64 High High
Lymphatic System Cancer 7 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apoptosis by lidocaine was strongly reduced by B-cell lymphoma-2 protein overexpression or caspase-9 deficiency, whereas cells lacking the death receptor pathway components caspase 8 and Fas-associated protein with death domain were not protected and displayed similar apoptotic alterations as the parental cells.
Gene_expression (overexpression) of caspase-9 in B-cell
1) Confidence 0.35 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0.07 Pain Relevance 0
Western blotting was used to demonstrate Bad, Bcl-2, Bax, caspase-9 and pro-caspase-3 expression.


Gene_expression (expression) of caspase-9
2) Confidence 0.34 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2924280 Disease Relevance 0.82 Pain Relevance 0
After PTL treatment at indicated concentrations for 48 hours, Caspase-9 and Pro-caspase-3 expressions of BxPC-3 cell were explored (Fig. 5C).
Gene_expression (expressions) of Caspase-9 in BxPC-3
3) Confidence 0.34 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.72 Pain Relevance 0
Effect of PTL at various concentrations on caspase-9 and caspase-3 expression
Gene_expression (expression) of caspase-9
4) Confidence 0.34 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.52 Pain Relevance 0
It was not surprising that HMW-HA did not decrease caspase-9 activation.
Gene_expression (activation) of caspase-9
5) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.19 Pain Relevance 0.04
HMW-HA significantly decreased UVB-induced caspases-3 and -8 activation but not caspase-9 activation
Gene_expression (activation) of caspase-9
6) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.38 Pain Relevance 0
Sulindac increased expression of ectopic MDA-7 protein in tumor cells, thereby increasing the expression of downstream effectors RNA-dependent protein kinase, p38MAPK, caspase-9, and caspase-3 and enhancing apoptosis of non-small cell lung cancer cells.
Gene_expression (expression) of caspase-9 in lung associated with lung cancer, cancer and apoptosis
7) Confidence 0.32 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15713900 Disease Relevance 1.13 Pain Relevance 0.06
m collapse, the release of cytoplasmatic cytochrome c and the presence of caspase-9 and -3 active forms were observed after a 6-hour exposure in LoVo and a 14-hour exposure in LRWZ cells (Fig. 5C and 5D).
Gene_expression (presence) of caspase-9 in LoVo associated with shock
8) Confidence 0.28 Published 2007 Journal J Transl Med Section Body Doc Link PMC2174440 Disease Relevance 1.07 Pain Relevance 0
CASP9 is a ubiquitously expressed protease which triggers the apoptotic pathway by releasing cytochrome c from mitochondria into the cytosol [73].
Gene_expression (expressed) of CASP9 associated with apoptosis
9) Confidence 0.22 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.01 Pain Relevance 0
Expression data was available for the following Bcl-2 genes: Bcl-2, Bfl-1 (BCL2A1), Bik, Bcl-w (BCL2L2), Bax, BCLAF1 (Bcl2-associated transcription factor 1); and for the following caspase genes: Caspase-1, Caspase-2, Caspase-3, Caspase-6, Caspase-8, Caspase-9, Caspase-10.
Gene_expression (genes) of Caspase-9
10) Confidence 0.21 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.33 Pain Relevance 0
We determined the effects of exercise on bcl-2 family upstream of caspase-3, including caspase-9 and bax: bcl-2 ratio.
Gene_expression (ratio) of caspase-9
11) Confidence 0.20 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.17 Pain Relevance 0
m and release of Cyto c were observed in NCTD-treated cells, resulting in caspase-9 and caspase-3 activation and PARP cleavage and, finally, apoptosis.
Gene_expression (activation) of caspase-9 in cleavage associated with apoptosis
12) Confidence 0.16 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.71 Pain Relevance 0
These results suggest that NCTD might induce apoptosis through Bcl-2/Bax, but not Bid, -mediated mitochondrial dysfunction pathway

Activation of caspase-9/caspase -3, PARP, but not caspase-8, is involved in NCTD-induced apoptosis

Gene_expression (caspase) of caspase-9 associated with parkinson's disease and apoptosis
13) Confidence 0.16 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 1.01 Pain Relevance 0
m and release of Cyto c were observed in NCTD-treated cells, resulting in caspase-9 and caspase-3 activation and PARP cleavage and, finally, apoptosis.
Gene_expression (cleavage) of caspase-9 in cleavage associated with apoptosis
14) Confidence 0.16 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.77 Pain Relevance 0
M of JNK inhibitor SP600125, or caspase-9 specific inhibitor Z-LEHD-fmk, or 10 ?
Gene_expression (specific) of caspase-9
15) Confidence 0.13 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.31 Pain Relevance 0
In the extrinsic death receptor/ligands pathway, caspase activation occurs as a direct consequence of death receptor ligation, with upstream caspase-8 cleaving and activating downstream proteases such as caspase-9 and caspase-3.
Gene_expression (cleaving) of caspase-9 associated with death
16) Confidence 0.13 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.95 Pain Relevance 0
In particular, in LoVo cells caspase-3 and -9 activation was already evident after 3 h, whereas in LWRZ, activation took a longer time to occur (at least 10 h for caspase-9 and 12 h for caspase-3).
Gene_expression (for) of caspase-9 in LoVo
17) Confidence 0.07 Published 2005 Journal J Transl Med Section Body Doc Link PMC549525 Disease Relevance 0.50 Pain Relevance 0.07
The induction of TP63 most likely lead to the increased expression of BAX, APAF1, and caspase-9 seen in WTSTS cells.
Gene_expression (expression) of caspase-9
18) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.54 Pain Relevance 0
cytochrome C release and caspase-9 activation.
Gene_expression (activation) of caspase-9
19) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.92 Pain Relevance 0
caspase-9 will finally cleave or activate the downstream effector caspases such
Gene_expression (cleave) of caspase-9
20) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.72 Pain Relevance 0

General Comments

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