INT125103

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.52
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP9) peptidase activity (CASP9) nucleus (CASP9)
intracellular (CASP9)
Anatomy Link Frequency
B-cell 2
lung 2
CASP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 57.80 Quite High
Inflammation 23 50.00 Quite Low
lidocaine 4 50.00 Quite Low
cytokine 20 29.68 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 14 99.68 Very High Very High Very High
Apoptosis 193 98.80 Very High Very High Very High
Lung Cancer 6 98.12 Very High Very High Very High
Stress 25 91.04 High High
INFLAMMATION 25 57.60 Quite High
Death 31 54.68 Quite High
Skin Cancer 1 54.36 Quite High
Repression 4 42.76 Quite Low
Infection 26 5.00 Very Low Very Low Very Low
Necrosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apoptosis by lidocaine was strongly reduced by B-cell lymphoma-2 protein overexpression or caspase-9 deficiency, whereas cells lacking the death receptor pathway components caspase 8 and Fas-associated protein with death domain were not protected and displayed similar apoptotic alterations as the parental cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of caspase-9 in B-cell
1) Confidence 0.31 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0.07 Pain Relevance 0
HMW-HA significantly decreased UVB-induced caspases-3 and -8 activation but not caspase-9 activation
Positive_regulation (activation) of Gene_expression (activation) of caspase-9
2) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.39 Pain Relevance 0
HMW-HA significantly decreased UVB-induced caspases-3 and -8 activation but not caspase-9 activation
Positive_regulation (induced) of Gene_expression (activation) of caspase-9
3) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.39 Pain Relevance 0
Sulindac increased expression of ectopic MDA-7 protein in tumor cells, thereby increasing the expression of downstream effectors RNA-dependent protein kinase, p38MAPK, caspase-9, and caspase-3 and enhancing apoptosis of non-small cell lung cancer cells.
Positive_regulation (increasing) of Gene_expression (expression) of caspase-9 in lung associated with lung cancer, cancer and apoptosis
4) Confidence 0.20 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15713900 Disease Relevance 1.13 Pain Relevance 0.06
The induction of TP63 most likely lead to the increased expression of BAX, APAF1, and caspase-9 seen in WTSTS cells.
Positive_regulation (increased) of Gene_expression (expression) of caspase-9
5) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.54 Pain Relevance 0

General Comments

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