INT125108

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.80
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna7) transport (Chrna7) plasma membrane (Chrna7)
cytoplasm (Chrna7)
Chrna7 (Mus musculus)
Pain Link Frequency Relevance Heat
methadone 11 99.60 Very High Very High Very High
imagery 1 92.96 High High
antagonist 9 83.64 Quite High
addiction 61 83.60 Quite High
opioid receptor 1 79.44 Quite High
agonist 6 78.64 Quite High
Antinociceptive 4 76.96 Quite High
Nicotine 27 76.72 Quite High
alcohol 25 70.24 Quite High
Dopamine 13 66.28 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 5 99.36 Very High Very High Very High
Hypothermia 2 75.60 Quite High
Drug Dependence 9 73.56 Quite High
Alcohol Addiction 7 70.68 Quite High
Targeted Disruption 2 36.44 Quite Low
Nicotine Addiction 19 5.00 Very Low Very Low Very Low
Cannabis Dependence 9 5.00 Very Low Very Low Very Low
Mental Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A series of 3'-substituted deschloroepibatidine analogues (3a-g and 4) showed high affinity for alpha4beta2 binding and relatively weak affinity for alpha7 nAChRs.
alpha7 Binding (binding) of
1) Confidence 0.47 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 15715488 Disease Relevance 0.08 Pain Relevance 0.31
A series of 3'-substituted deschloroepibatidine analogues (3a-g and 4) showed high affinity for alpha4beta2 binding and relatively weak affinity for alpha7 nAChRs.
alpha7 Binding (affinity) of
2) Confidence 0.35 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 15715488 Disease Relevance 0.08 Pain Relevance 0.31
Consequently, the linkage of the CHRM5-CHRNA7 haplotype with schizophrenia is unlikely to represent evidence due to linkage disequilibrium with functional markers in either gene.


CHRNA7 Binding (linkage) of associated with schizophrenia
3) Confidence 0.26 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.65 Pain Relevance 0.32
Methadone potently inhibited binding of [3H]methyllycaconitine to alpha7 nAChRs and that of [3H]epibatidine to alpha3* nAChRs.
alpha7 Binding (binding) of associated with methadone
4) Confidence 0.06 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000156 Disease Relevance 0 Pain Relevance 1.08

General Comments

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