INT125136

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 7
Speculated 6
Reported most in Body
Documents 24
Total Number 30
Disease Relevance 16.82
Pain Relevance 7.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 7
adipose tissue 3
coronary artery 1
uterus 1
fat 1
Adipoq (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 51 100.00 Very High Very High Very High
agonist 133 99.82 Very High Very High Very High
Migraine 16 99.68 Very High Very High Very High
fluoxetine 8 98.76 Very High Very High Very High
addiction 3 98.68 Very High Very High Very High
qutenza 11 98.32 Very High Very High Very High
Spinal cord 12 97.96 Very High Very High Very High
Angina 20 97.44 Very High Very High Very High
Hyperalgesia 21 96.92 Very High Very High Very High
Inflammation 55 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 123 100.00 Very High Very High Very High
Impaired Glucose Tolerance 52 100.00 Very High Very High Very High
Insulin Resistance 78 99.96 Very High Very High Very High
Headache 17 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 8 99.04 Very High Very High Very High
Cv General 4 Under Development 1 99.00 Very High Very High Very High
Opiate Addiction 3 98.96 Very High Very High Very High
Coronary Artery Disease 24 98.48 Very High Very High Very High
Stroke 2 97.76 Very High Very High Very High
Variant Angina Pectoris 10 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rats on HF diet showed significant increases in postprandial serum triglycerides, free fatty acids (FFA), insulin, and area under curve (AUC) of serum insulin during an oral glucose tolerance test, but showed no change in serum glucose, adiponectin, and glucose AUC.
Neg (no) Regulation (change) of adiponectin associated with tolerance and impaired glucose tolerance
1) Confidence 0.56 Published 2004 Journal BMC Pharmacol Section Abstract Doc Link PMC526775 Disease Relevance 0.29 Pain Relevance 0.31
There were no statistically significant changes in adiponectin levels in the control group.
Neg (no) Regulation (changes) of adiponectin
2) Confidence 0.50 Published 2008 Journal Clin Cardiol Section Body Doc Link 18543304 Disease Relevance 0.20 Pain Relevance 0
Furthermore, our results showed that Acrp30 fluctuated during the estrous cycle, suggesting that steroid hormones play a role in the regulation of Acrp30.
Regulation (regulation) of Acrp30
3) Confidence 0.49 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.19 Pain Relevance 0
Furthermore, it has been suggested that hypervolemic conditions in patient populations may modulate the effect of plasma adiponectin levels [57].
Spec (may) Regulation (modulate) of adiponectin in plasma
4) Confidence 0.48 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.74 Pain Relevance 0.17
Leptin and adiponectin levels were not different between the control group and fluoxetine-treated group, indicating that these factors were not involved in the observed changes in bone geometry and quality.
Neg (not) Regulation (different) of adiponectin associated with fluoxetine
5) Confidence 0.44 Published 2007 Journal J. Cell. Biochem. Section Abstract Doc Link 17163489 Disease Relevance 0.08 Pain Relevance 0.41
Thus, our study aimed to assess the effects of fish oil rich dietetic intervention on glucose tolerance, serum insulin and adiponectin, and adipose tissue gene expression of adiponectin and TNF-?
Regulation (effects) of adiponectin in adipose tissue associated with obesity, tolerance and impaired glucose tolerance
6) Confidence 0.43 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.76 Pain Relevance 0.05
The major finding of the present study was the reduction in adiponectin retroperitoneal adipose tissue gene expression in PSD rats when compared to control rats, not accompanied by alterations in epididymal adipose tissue for adiponectin and TNF-?
Regulation (alterations) of adiponectin in adipose tissue associated with obesity
7) Confidence 0.43 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.54 Pain Relevance 0.13
Adiponectin and resistin are proteins that affect insulin resistance and atherosclerosis significantly.
Regulation (affect) of Adiponectin associated with increased venous pressure under development and insulin resistance
8) Confidence 0.39 Published 2008 Journal Atherosclerosis Section Abstract Doc Link 17178123 Disease Relevance 0.80 Pain Relevance 0
As leptin and adiponectin could be possible factors in the serotonergic regulation of bone metabolism, we also determined the levels of these factors in plasma samples of all animals.
Spec (possible) Regulation (regulation) of adiponectin in plasma
9) Confidence 0.39 Published 2007 Journal J. Cell. Biochem. Section Abstract Doc Link 17163489 Disease Relevance 0.09 Pain Relevance 0.43
In a second group of rats, plasma and spinal cord samples collected after three and six weeks of placebo or stavudine administration were examined for changes in CINC-1, IL-6, adiponectin (plasma only) and lactate (plasma only) concentration.
Spec (examined) Regulation (changes) of adiponectin in spinal cord associated with spinal cord
10) Confidence 0.37 Published 2009 Journal Neurotoxicology Section Abstract Doc Link 19442827 Disease Relevance 1.03 Pain Relevance 0.76
The anti-inflammatory, anti-atherogenic effects of Atorvastatin are not affected by decreased adiponectin levels.


Neg (not) Regulation (affected) of adiponectin
11) Confidence 0.37 Published 2008 Journal Clin Cardiol Section Body Doc Link 18543304 Disease Relevance 0 Pain Relevance 0
agonist, class of insulin sensitizer, has the marked effect of up-regulating serum adiponectin.
Regulation (regulating) of serum adiponectin associated with agonist
12) Confidence 0.36 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.74 Pain Relevance 0.13
agonist [36] up-regulated the adiponectin mRNA level in the small size adipocytes.
Regulation (regulated) of adiponectin mRNA in adipocytes associated with obesity and agonist
13) Confidence 0.27 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275770 Disease Relevance 0.53 Pain Relevance 0.05
AIMS: To determine the prognostic value of baseline plasma adiponectin levels in patients with known or suspected coronary artery disease referred for coronary angiography.
Spec (determine) Regulation (value) of adiponectin in coronary artery associated with coronary artery disease
14) Confidence 0.27 Published 2006 Journal Eur. Heart J. Section Abstract Doc Link 16864609 Disease Relevance 0.25 Pain Relevance 0.07
No significant alteration in the serum insulin (Fig. 4) and adiponectin (Fig. 5) was observed in the four groups evaluated.


Neg (No) Regulation (alteration) of adiponectin
15) Confidence 0.26 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.36 Pain Relevance 0.07
Gender-specific median values of adiponectin were used to separate the higher group from the lower group, and the Kaplan-Meier curve showed a significantly lower event-free survival rate in the lower adiponectin group (<4.39 microg/ml in men, <6.84 microg/ml in women, chi-square 4.88, p <0.03).
Regulation (values) of adiponectin
16) Confidence 0.23 Published 2006 Journal Am. J. Cardiol. Section Abstract Doc Link 17145218 Disease Relevance 1.35 Pain Relevance 0.10
BACKGROUND: There is controversy about the effects of statins on plasma adiponectin, and the impact of percutaneous coronary intervention (PCI) on plasma adiponectin level is still unknown.
Regulation (effects) of adiponectin in plasma
17) Confidence 0.22 Published 2008 Journal Clin Cardiol Section Abstract Doc Link 18543304 Disease Relevance 0.07 Pain Relevance 0.08
Changes of adiponectin level were not associated with the changes of high-sensitivity C-reactive protein (hs-CRP) and lipid profiles in the Atorvastatin group.
Regulation (Changes) of adiponectin
18) Confidence 0.22 Published 2008 Journal Clin Cardiol Section Body Doc Link 18543304 Disease Relevance 0.18 Pain Relevance 0
To investigate the regulation of various genes in the uterus of rats during estrous cycle, the expression levels of CaBP-9k, oxytocin, Acrp30, Ldha, and S100a6 mRNA were analyzed by real-time PCR.
Spec (investigate) Regulation (regulation) of Acrp30 in uterus
19) Confidence 0.22 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
Plasma adiponectin concentrations in VAP and ACS were significantly lower than that of the normal coronary group (6.6+/-5.4 vs 5.2+/-4.0 vs 9.0 +/-6.2 microg/ml, p<0.001, respectively).
Regulation (concentrations) of Plasma adiponectin in Plasma
20) Confidence 0.21 Published 2006 Journal Circ. J. Section Body Doc Link 16565557 Disease Relevance 0.09 Pain Relevance 0

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