INT125138

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 11.94
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (RETN) extracellular region (RETN) nucleus (RETN)
biological_process (RETN)
Anatomy Link Frequency
plasma 4
coronary artery 1
foot 1
RETN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 165 100.00 Very High Very High Very High
psoriasis 20 99.42 Very High Very High Very High
Angina 7 99.28 Very High Very High Very High
Chronic pancreatitis 6 98.72 Very High Very High Very High
cytokine 48 97.08 Very High Very High Very High
fibrosis 2 96.68 Very High Very High Very High
methadone 3 88.40 High High
addiction 3 86.96 High High
Inflammatory response 3 80.64 Quite High
alcohol 5 78.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 179 100.00 Very High Very High Very High
Coronary Artery Disease 20 100.00 Very High Very High Very High
Depression 59 99.56 Very High Very High Very High
Increased Venous Pressure Under Development 32 99.44 Very High Very High Very High
Psoriasis 20 99.42 Very High Very High Very High
Cv General 3 Under Development 6 99.28 Very High Very High Very High
Polycystic Ovary Syndrome 83 99.04 Very High Very High Very High
Diabetes Mellitus 209 98.80 Very High Very High Very High
Pancreatitis 6 98.72 Very High Very High Very High
Insulin Resistance 62 98.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Basal serum leptin and adiponectin levels in heroin addicts were significantly decreased (3.4+/-0.4 vs. 4.5+/-0.6 ng/ml and 18.9+/-3.3 vs. 33.9+/-3.1 ng/microl, respectively; p 0.05) while serum resistin concentrations were increased compared to healthy subjects (10.1+/-1.2 vs. 4.6+/-0.3 ng/ml; p 0.05).
Positive_regulation (increased) of resistin
1) Confidence 0.67 Published 2005 Journal Physiol Res Section Abstract Doc Link 15717844 Disease Relevance 0.57 Pain Relevance 0.36
The slight reduction in vitamin C plasma levels of the control individuals corresponded to a small increase in their serum resistin values.
Positive_regulation (increase) of resistin in plasma
2) Confidence 0.51 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.20 Pain Relevance 0.04
In the control group, unexpectedly, we observed a slight, statistically significant reduction in vitamin C plasma levels and a small increase in serum resistin values (Figure 3).
Positive_regulation (increase) of resistin in plasma
3) Confidence 0.51 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.71 Pain Relevance 0.16
In humans, a small study testing the effect of a chronic treatment with retinoid therapy on patients with psoriasis showed normalization of the increased resistin serum levels, together with a reduction in insulin sensitivity, without any changes in circulating adiponectin or tumor necrosis factor concentrations [25].
Positive_regulation (increased) of resistin associated with psoriasis, necrosis and cancer
4) Confidence 0.51 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.54 Pain Relevance 0.08
Resistin levels were reported to increase in coronary artery disease (CAD), while data concerning resistin in different stages of CAD in Chinese people are lacking.
Positive_regulation (increase) of Resistin in coronary artery associated with coronary artery disease
5) Confidence 0.50 Published 2007 Journal Chin. Med. J. Section Abstract Doc Link 17543176 Disease Relevance 0.75 Pain Relevance 0.16
In a sample of 3289 community residents from Beijing and Shanghai, we found no evidence that depressive symptoms were associated with increased levels of various inflammatory factors (CRP and IL-6) and adipokines (adiponectin, resistin, PAI-1 and RBP4).
Positive_regulation (increased) of resistin associated with depression and inflammation
6) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.46 Pain Relevance 0.29
In our study both univariate and multivariate analysis showed the predictive positive role of resistin and IL-6 plasma levels and a negative one of adyponectin towards diabetic foot presence.
Positive_regulation (role) of resistin in foot associated with diabetic foot ulcer
7) Confidence 0.38 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946274 Disease Relevance 1.20 Pain Relevance 0.27
In humans, a small study on patients with psoriasis showed normalization of the increased resistin serum levels after treatment with retinoid therapy [25].
Positive_regulation (increased) of resistin associated with psoriasis
8) Confidence 0.34 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.32 Pain Relevance 0.09
Plasma resistin is increased in patients with unstable angina.
Positive_regulation (increased) of resistin in Plasma associated with angina
9) Confidence 0.33 Published 2007 Journal Chin. Med. J. Section Title Doc Link 17543176 Disease Relevance 0.74 Pain Relevance 0.18
RESULTS: Plasma concentrations of resistin were significantly increased in UAP group (geometric mean (interquartile range) 12.09 ng/ml (8.40, 18.08)) in comparison with SAP (9.04 ng/ml (7.09, 11.44)) and control groups (8.71 ng/ml (6.58, 11.56)).
Positive_regulation (increased) of resistin in Plasma
10) Confidence 0.33 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17543176 Disease Relevance 0.09 Pain Relevance 0
Others have reported that there is an increase in serum resistin level in patients with PCOS (Munir et al 2005), although it has been suggested that this increase is dependent on BMI (Panidis et al 2004).
Positive_regulation (increase) of resistin associated with obesity and polycystic ovary syndrome
11) Confidence 0.27 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.96 Pain Relevance 0.05
Moreover, Osawa et al [19] reported that elevated serum resistin concentration appears to be an independent risk factor for ischemic stroke, especially lacunar and atherothrombotic infarction in the general Japanese population.
Positive_regulation (elevated) of resistin associated with stroke and infarction
12) Confidence 0.22 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946274 Disease Relevance 1.77 Pain Relevance 0.27
Increased serum resistin concentration in patients with chronic pancreatitis: possible cause of pancreatic fibrosis.
Spec (possible) Positive_regulation (Increased) of resistin associated with fibrosis and chronic pancreatitis
13) Confidence 0.20 Published 2009 Journal J. Clin. Gastroenterol. Section Title Doc Link 18827713 Disease Relevance 0.20 Pain Relevance 0.33
CONCLUSIONS: The results presented in this paper indicate that chronic pancreatitis in human is associated with the increase in serum resistin concentration and with the decrease in serum leptin and insulin concentrations.
Positive_regulation (increase) of resistin
14) Confidence 0.20 Published 2009 Journal J. Clin. Gastroenterol. Section Body Doc Link 18827713 Disease Relevance 0.05 Pain Relevance 0
The role of resistin in insulin resistance and diabetes is controversial since a number of studies have shown that resistin levels increase with increased central adiposity and other studies have demonstrated a significant decrease in resistin levels in increased adiposity.
Positive_regulation (increase) of resistin associated with diabetes mellitus and insulin resistance
15) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.40 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox