INT125140

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.65
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (EPHB4) plasma membrane (EPHB4)
Anatomy Link Frequency
venous endothelium 2
ECs 1
vessels 1
veins 1
EPHB4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 87.04 High High
Dopamine 83 76.64 Quite High
midbrain 20 67.76 Quite High
nMDA receptor 9 66.12 Quite High
isoflurane 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vascular Malformations 10 98.88 Very High Very High Very High
Hypertrophy 5 89.56 High High
Pain 5 87.04 High High
Hypoxia 144 56.16 Quite High
Ganglion Cysts 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 7 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In venous malformations, the expression of EphB4 is not altered, but both ephrinB2 and EphB2 are ectopically expressed in venous ECs.
Gene_expression (expression) of EphB4 in ECs
1) Confidence 0.62 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.24 Pain Relevance 0.05
In mice, some ephrin/Eph family members show a complementary expression pattern in blood vessels, with ephrinB2 being expressed on arterial and EphB4 on venous endothelium.
Gene_expression (expressed) of EphB4 in venous endothelium
2) Confidence 0.62 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.35 Pain Relevance 0.09
Here, we have defined the expression patterns of human ephrinB2, EphB4, and EphB2 in normal vessels of neonates (i.e. umbilici) and adults and compared them with those in congenital venous malformations.
Gene_expression (expression) of EphB4 in vessels
3) Confidence 0.62 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.33 Pain Relevance 0.08
In adults, normal vessels of the skin, muscle, and legs express ephrinB2 and EphB2 on arterial endothelial cells (ECs), whereas EphB4 is found in arteries and veins.
Gene_expression (found) of EphB4 in veins
4) Confidence 0.62 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.28 Pain Relevance 0.06
In mice, some ephrin/Eph family members show a complementary expression pattern in blood vessels, with ephrinB2 being expressed on arterial and EphB4 on venous endothelium.
Gene_expression (expressed) of EphB4 in venous endothelium
5) Confidence 0.54 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.35 Pain Relevance 0.09
Expression of ephrin B1 receptors EPHB2 and EPHB4 was also detected in undifferentiated hESC.
Gene_expression (Expression) of EPHB4
6) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.13
Ten were not represented (AKAP9, BAIAP1, CASR, DLG2, EPHB4, GRIN3B, GUCY2C, GUCY2D, NPR2, and PRKCABP).
Neg (not) Gene_expression (represented) of EPHB4
7) Confidence 0.10 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.11 Pain Relevance 0.12

General Comments

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