INT125142

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 9
Disease Relevance 2.59
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (EFNB2) cell adhesion (EFNB2) plasma membrane (EFNB2)
cell-cell signaling (EFNB2)
Anatomy Link Frequency
vessels 3
veins 3
venous endothelium 2
ECs 1
EFNB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 9 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vascular Malformations 18 98.88 Very High Very High Very High
Pain 9 95.24 Very High Very High Very High
Hypertrophy 9 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In venous malformations, the expression of EphB4 is not altered, but both ephrinB2 and EphB2 are ectopically expressed in venous ECs.
Gene_expression (expressed) of ephrinB2 in ECs
1) Confidence 0.24 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.23 Pain Relevance 0.05
Here, we have defined the expression patterns of human ephrinB2, EphB4, and EphB2 in normal vessels of neonates (i.e. umbilici) and adults and compared them with those in congenital venous malformations.
Gene_expression (expression) of ephrinB2 in vessels
2) Confidence 0.24 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.33 Pain Relevance 0.08
Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformations.
Gene_expression (patterns) of EphrinB2 in vessels
3) Confidence 0.24 Published 2005 Journal Pediatr. Res. Section Title Doc Link 15718372 Disease Relevance 0.36 Pain Relevance 0.10
In adults, normal vessels of the skin, muscle, and legs express ephrinB2 and EphB2 on arterial endothelial cells (ECs), whereas EphB4 is found in arteries and veins.
Gene_expression (express) of ephrinB2 in veins
4) Confidence 0.24 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.29 Pain Relevance 0.07
In mice, some ephrin/Eph family members show a complementary expression pattern in blood vessels, with ephrinB2 being expressed on arterial and EphB4 on venous endothelium.
Gene_expression (expressed) of ephrinB2 in venous endothelium
5) Confidence 0.24 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.35 Pain Relevance 0.09
In the umbilicus, EphB2 is a specific marker of arterial ECs, whereas ephrinB2 is additionally expressed in venous ECs, suggesting an arterial function of the veins.
Gene_expression (expressed) of ephrinB2 in veins
6) Confidence 0.24 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.26 Pain Relevance 0.06
Our study shows that the arterial markers ephrin B2 and EphB2 are expressed in a subset of veins, and it remains to be studied whether this is cause or consequence of an altered vascular identity.
Gene_expression (expressed) of ephrin B2 in veins
7) Confidence 0.24 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.07 Pain Relevance 0
In mice, some ephrin/Eph family members show a complementary expression pattern in blood vessels, with ephrinB2 being expressed on arterial and EphB4 on venous endothelium.
Gene_expression (expressed) of ephrinB2 in venous endothelium
8) Confidence 0.21 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.35 Pain Relevance 0.09
Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformations.
Gene_expression (expression) of EphrinB2 in vessels
9) Confidence 0.19 Published 2005 Journal Pediatr. Res. Section Title Doc Link 15718372 Disease Relevance 0.36 Pain Relevance 0.10

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