INT125143

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Context Info
Confidence 0.71
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 13.27
Pain Relevance 6.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPHB2)
Anatomy Link Frequency
brain 3
vessels 3
veins 3
plasma 1
chondrocytes 1
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 6 100.00 Very High Very High Very High
Sciatic nerve 4 100.00 Very High Very High Very High
dorsal rhizotomy 4 100.00 Very High Very High Very High
Osteoarthritis 599 99.08 Very High Very High Very High
Inflammatory response 23 98.54 Very High Very High Very High
Kinase C 34 98.48 Very High Very High Very High
COX2 83 98.42 Very High Very High Very High
metalloproteinase 180 97.80 Very High Very High Very High
Pain 28 95.64 Very High Very High Very High
Inflammation 587 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 613 99.08 Very High Very High Very High
Vascular Malformations 14 98.88 Very High Very High Very High
Infection 49 98.46 Very High Very High Very High
INFLAMMATION 596 98.34 Very High Very High Very High
Cancer 538 97.32 Very High Very High Very High
Pain 28 95.64 Very High Very High Very High
Adhesions 19 95.08 Very High Very High Very High
Ovarian Cancer 85 94.24 High High
Apoptosis 232 93.84 High High
Hypertrophy 19 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study shows that the arterial markers ephrin B2 and EphB2 are expressed in a subset of veins, and it remains to be studied whether this is cause or consequence of an altered vascular identity.
Gene_expression (expressed) of EphB2 in veins
1) Confidence 0.71 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.07 Pain Relevance 0
In adults, normal vessels of the skin, muscle, and legs express ephrinB2 and EphB2 on arterial endothelial cells (ECs), whereas EphB4 is found in arteries and veins.
Gene_expression (express) of EphB2 in veins
2) Confidence 0.71 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.29 Pain Relevance 0.07
Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformations.
Gene_expression (expression) of EphB2 in vessels
3) Confidence 0.71 Published 2005 Journal Pediatr. Res. Section Title Doc Link 15718372 Disease Relevance 0.36 Pain Relevance 0.10
Here, we have defined the expression patterns of human ephrinB2, EphB4, and EphB2 in normal vessels of neonates (i.e. umbilici) and adults and compared them with those in congenital venous malformations.
Gene_expression (expression) of EphB2 in vessels
4) Confidence 0.71 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.33 Pain Relevance 0.08
In venous malformations, the expression of EphB4 is not altered, but both ephrinB2 and EphB2 are ectopically expressed in venous ECs.
Gene_expression (expressed) of EphB2 in ECs
5) Confidence 0.71 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15718372 Disease Relevance 0.23 Pain Relevance 0.05
induced pro-inflammatory responses including: (1) assembly of plasma membrane actin; (2) activation of MAP kinases ERK and p38; and (3) activation of NF-?
Gene_expression (kinases) of ERK in plasma associated with inflammatory response
6) Confidence 0.65 Published 2010 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC2996791 Disease Relevance 0.88 Pain Relevance 0.23
, MAP kinases, ERK1/2 and Fos/Jun (Figure S4).
Gene_expression (/) of ERK1
7) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0 Pain Relevance 0.03
The involvement of signaling pathways (JNK, p38, and Erk1/2 MAP-kinases, JAK2 and JAK3, PKC, and transcription factor NF-?
Gene_expression (kinases) of Erk1
8) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.39 Pain Relevance 0.24
M (Erk1/2 inhibitor), AG490 10 ?
Gene_expression (/) of Erk1
9) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.29 Pain Relevance 0.15
M) and PD 98059 (Erk1/2 inhibitor; 10 ?
Gene_expression (/) of Erk1
10) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.21 Pain Relevance 0.17
1-integrin, Shc, activated ERK 1/2 and Sox-9 (Figure 3C).
Gene_expression (/) of ERK 1
11) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.35 Pain Relevance 0
In particular, EGFR and HER2/neu activate signaling pathways (PI3K/Akt and ERK1/2 MAP kinase), leading to different cellular processes involved in tumor development, such as cell division and migration, adhesion, differentiation, and apoptosis [58].
Gene_expression (/) of ERK1 associated with cancer, apoptosis and adhesions
12) Confidence 0.65 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.22 Pain Relevance 0
Neonatal rat cardiomyocyte contraction assay and the detection of extracellular regulated kinase 1/2 (ERK1/2) phosphorylation in CHO cells stably transfected with human ?
Gene_expression (detection) of ERK1 in cardiomyocyte
13) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.30 Pain Relevance 0.17
While altered expression of MAPK/ERK pathway elements was not detected in this study, changes in expression and activity levels of MAPK/ERK genes have been reported (for a review see [28]) and this pathway is thought to play an important role in drug-induced changes in the brain [53,54].
Gene_expression (expression) of ERK in brain
14) Confidence 0.65 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.07 Pain Relevance 0.24
While altered expression of MAPK/ERK pathway elements was not detected in this study, changes in expression and activity levels of MAPK/ERK genes have been reported (for a review see [28]) and this pathway is thought to play an important role in drug-induced changes in the brain [53,54].
Gene_expression (expression) of ERK in brain
15) Confidence 0.65 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.07 Pain Relevance 0.28
Network analysis was conducted using the set of confirmed mPFC gene expression changes, and revealed that Cart, NPY, Nr4a1, Fos, Egr1, Adora2b and Drd5 all interact (directly or indirectly) with the MAPK/ERK pathway.
Gene_expression (pathway) of ERK
16) Confidence 0.65 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.08 Pain Relevance 0.25
While altered expression of MAPK/ERK pathway elements was not detected in this study, changes in expression and activity levels of MAPK/ERK genes have been reported (for a review see [28]) and this pathway is thought to play an important role in drug-induced changes in the brain [53,54].
Gene_expression (expression) of ERK in brain
17) Confidence 0.65 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.07 Pain Relevance 0.27
Effects of VPA on individual cell motility by modulation of signal transduction upstream of Erk1/2
Gene_expression (/) of Erk1
18) Confidence 0.65 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
1-integrin, Shc, activated ERK 1/2 and Sox-9.
Gene_expression (/) of ERK 1
19) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.12 Pain Relevance 0
in turn activated the Rho-GTPase/MEK1/ERK1/2 cascade, resulting in
Gene_expression (/) of ERK1
20) Confidence 0.65 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.62 Pain Relevance 0.15

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