INT125147

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.55
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc4r) plasma membrane (Mc4r) signal transducer activity (Mc4r)
Mc4r (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 44 99.96 Very High Very High Very High
Central nervous system 68 97.20 Very High Very High Very High
addiction 20 96.20 Very High Very High Very High
agonist 65 92.48 High High
cocaine 16 88.92 High High
Glutamate 4 84.56 Quite High
Opioid 22 82.80 Quite High
drug abuse 4 81.56 Quite High
alcohol 2 79.20 Quite High
gABA 32 61.36 Quite High
Disease Link Frequency Relevance Heat
Appetite Loss 40 100.00 Very High Very High Very High
Obesity 371 99.66 Very High Very High Very High
Eating Disorder 6 98.20 Very High Very High Very High
Anorexia 56 91.72 High High
Opiate Addiction 2 83.24 Quite High
Drug Dependence 6 81.56 Quite High
Body Weight 43 81.00 Quite High
Alcohol Addiction 2 79.64 Quite High
Weight Gain 16 79.40 Quite High
Adhesions 2 73.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also confirmed the significant associations with FTO and MC4R that have previously been reported.
MC4R Binding (associations) of
1) Confidence 0.41 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2695005 Disease Relevance 0.66 Pain Relevance 0.08
Pro-opimelanocortin, which produces a ligand for MC4R ?
MC4R Binding (ligand) of
2) Confidence 0.39 Published 2010 Journal BMC Genet Section Body Doc Link PMC2955677 Disease Relevance 0.76 Pain Relevance 0
CONCLUSIONS: These results indicate that blockade of MC4 receptors increases the antinociceptive effects of morphine without changing the potency of morphine for locomotor activity, suggesting that MC4 receptor antagonists may be candidate drugs that can be clinically used for the treatment of pain.


MC4 Binding (blockade) of
3) Confidence 0.37 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15719225 Disease Relevance 0 Pain Relevance 0
Other well-replicated obesity loci, including MC4R, have also been shown to be associated with centrally-mediated phenomena including binge eating behavior [11],[12],[27].
MC4R Binding (associated) of associated with obesity and eating disorder
4) Confidence 0.36 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2695005 Disease Relevance 0.75 Pain Relevance 0.46
Prior administration of the MC3R/MC4R antagonist SHU9119 abolishes nesfatin-1-induced feeding suppression, but nesfatin-1 does not show any direct agonistic action on MC3R or MC4R.
MC4R Binding (administration) of associated with appetite loss and antagonist
5) Confidence 0.36 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.19 Pain Relevance 0.05
Both AgRP and the MSHs can bind to MC3R and MC4R either presynaptically or postsynaptically [10,11].
MC4R Binding (bind) of
6) Confidence 0.35 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.18 Pain Relevance 0.36
-MSH has a higher affinity for the MC4R than ?
MC4R Binding (affinity) of
7) Confidence 0.32 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.24 Pain Relevance 0
These data are consistent with MC4R being the principal anorectic receptor in mammals, with either ?
MC4R Binding (receptor) of associated with appetite loss
8) Confidence 0.32 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.77 Pain Relevance 0.08
Wild-type MC4R was expressed on the cell surface and internalized after treatment with 1 ┬ÁM ?
MC4R Binding (internalized) of
9) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0 Pain Relevance 0.05
50), or against COUP-TFII and MC4-R (goat anti MC4-R polyclonal antibody, R-19, Santa Cruz, dilution 1?
MC4-R Binding (against) of
10) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0

General Comments

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