INT125187

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 8.98
Pain Relevance 5.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
kidney 3
neuronal 2
neurons 2
DRG 2
nociceptors 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 145 99.84 Very High Very High Very High
Inflammation 88 99.78 Very High Very High Very High
dorsal root ganglion 139 99.20 Very High Very High Very High
Gabapentin 1 98.40 Very High Very High Very High
induced neuropathy 24 97.68 Very High Very High Very High
c fibre 37 97.64 Very High Very High Very High
unmyelinated 11 96.84 Very High Very High Very High
Hyperalgesia 71 93.88 High High
qutenza 88 93.80 High High
nociceptor 83 93.72 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 437 99.84 Very High Very High Very High
INFLAMMATION 86 99.78 Very High Very High Very High
Cold Sores 136 99.64 Very High Very High Very High
Cancer 24 98.12 Very High Very High Very High
Neuropathic Pain 87 97.68 Very High Very High Very High
Fibrosarcoma 4 97.64 Very High Very High Very High
Nervous System Injury 24 94.28 High High
Hyperalgesia 134 93.88 High High
Nociception 48 90.96 High High
Targeted Disruption 37 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the increase in TRPV1 mRNA expression in TG in vivo mirrored that observed in DRG in vitro.
Positive_regulation (increase) of Transcription (expression) of TRPV1 associated with dorsal root ganglion and trigeminal ganglion
1) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.32 Pain Relevance 0.83
With peripheral inflammation, the mRNA expression of TRPV1 and ASIC3 is increased in dorsal root ganglia (DRG) and sensitizes their responses [15-20].
Positive_regulation (increased) of Transcription (expression) of TRPV1 in DRG associated with inflammation
2) Confidence 0.63 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.22 Pain Relevance 1.06
Given the increased levels of TRPV1 mRNA that were found in the sensory nerve cell bodies, increased TRPV1 expression could result in enhanced TRPV1 protein trafficking to peripheral terminal nociceptors.
Positive_regulation (increased) of Transcription (levels) of TRPV1 in nociceptors associated with nociceptor
3) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.29 Pain Relevance 0.91
Similarly, inflammation was also reported to increase the proportion of TRPV1 protein-positive neurons but not the mRNA level of the TRPV1 receptor in DRGs [74].
Positive_regulation (increase) of Transcription (level) of TRPV1 in neurons associated with inflammation
4) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.03 Pain Relevance 0.87
After KM (700 mg/kg s.c. b.i.d., 14 days), TRPV1 mRNA and protein expression were significantly up-regulated both in the spiral and vestibular ganglia, but expression was unaffected in the trigeminal ganglion and kidney.
Positive_regulation (up-regulated) of Transcription (expression) of TRPV1 in kidney associated with ganglion cysts and trigeminal ganglion
5) Confidence 0.46 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.10 Pain Relevance 0.23
In DRG injected with the HSV-U6shLacZ vector, TRPV1 mRNA levels were essentially unchanged compared to the right DRG.
Neg (unchanged) Positive_regulation (unchanged) of Transcription (levels) of TRPV1 associated with dorsal root ganglion and cold sores
6) Confidence 0.45 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.58 Pain Relevance 0.47
Correspondingly, TRPV1 transcript levels are increased by 61% (RT-PCR), whereas TRPV2, V3 and V4 transcripts are unchanged.
Positive_regulation (increased) of Transcription (levels) of TRPV1
7) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.43 Pain Relevance 0.07
TRPV1 transcript levels are increased in these animals but ASIC2 transcript levels are decreased.
Positive_regulation (increased) of Transcription (levels) of TRPV1
8) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.27
Fig 2A shows that, when comparing samples containing an equal amount of the housekeeping gene GAPDH mRNA, there was significant upregulation of P2X3 and TRPV1 transcripts for rat and mouse neurons in vitro with respect to the ganglion after normalization for the neuronal-specific ?
Positive_regulation (upregulation) of Transcription (transcripts) of TRPV1 in neuronal associated with ganglion cysts
9) Confidence 0.29 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.50 Pain Relevance 0.04
The increased responses were associated with increased mRNA levels for the Ca2+ channel subunit alpha2delta1 and TRPV1 receptor.
Positive_regulation (increased) of Transcription (levels) of TRPV1 receptor
10) Confidence 0.20 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17881535 Disease Relevance 1.42 Pain Relevance 0.79
After KM (700 mg/kg s.c. b.i.d., 14 days), TRPV1 mRNA and protein expression were significantly up-regulated both in the spiral and vestibular ganglia, but expression was unaffected in the trigeminal ganglion and kidney.
Positive_regulation (up-regulated) of in trigeminal ganglion Transcription (expression) of TRPV1 in kidney associated with ganglion cysts and trigeminal ganglion
11) Confidence 0.16 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.10 Pain Relevance 0.23

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