INT125190
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
We summarize disease-related changes in TRPV1 expression and its implications for therapy and potential adverse effects. | |||||||||||||||
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These findings demonstrate that altered TRPV1 expression and function contribute to diabetes-induced changes in thermal perception.
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There was no change in the number of neurons expressing TRPV1 in hypoalgesic mice relative to controls.
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To determine whether cisplatin and oxaliplatin induced changes in TRPV1 protein expression, immunostaining of TRPV1 protein was performed in the TG of wild-type mice after a 3-week platinum drug treatment protocol [48]. | |||||||||||||||
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Changes in blood glucose level, body weight and thermal pain sensitivity in TRPV1 knock-out mice injected with STZ | |||||||||||||||
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Changes in blood glucose level, body weight and thermal pain sensitivity in TRPV1 knock-out mice injected with STZ | |||||||||||||||
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Since TRPV1 is involved in inflammatory thermal sensation, it is logical to determine the expression and function of TRPV1 in DPN. | |||||||||||||||
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Consequences of enhanced and reduced TRPV1 expression and function other than abnormal thermal sensation | |||||||||||||||
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Together, these results suggest the possibilities that TRPV1 channels in the bladder and urethra are involved in the sex difference in the LUT response to acid irritation and that these participate, e.g., via "cross talk" between the bladder and urethra, in the fine-tuning of intravesical pressure (or bladder emptying) at the bladder contraction phase under irritated LUT conditions but not in sensing for bladder filling during the storage period, although the contribution of the mechanism may be small. | |||||||||||||||
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For example, it has been shown that TRPV1 sensitivity can be significantly modulated by many of the components of the inflammatory milieu (e.g. bradykinin, and NGF) present in inflamed skin as well as by local decreases in pH [2,52-54], that in turn could result in local peptide release in the inflamed tissue contributing to neurogenic inflammation [3]. | |||||||||||||||
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In this study, we used models of cisplatin and oxaliplatin-induced neuropathy to investigate whether TRPV1, TRPM8, and TRPA1 mRNA expression were altered along with changes in thermal sensitivity observed in chemotherapeutic neuropathy. | |||||||||||||||
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Thus, in this pain model, cisplatin treatment did not result in an overall change in the proportion of TRPV1 immunoreactive TG neurons. | |||||||||||||||
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To characterize the population of TRPV1-protein positive neurons, we measured cell soma diameters in TRPV1-immunoreactive TG cells and observed average values of 16.66 ± 3.59 ? | |||||||||||||||
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To determine whether the neurotoxic effects on the peripheral nervous system from platinum drug exposure induces changes in the expression of TRPV1, TRPM8, and TRPA1 mRNA, we used a previously described cell culture model [50]. | |||||||||||||||
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In these experiments we assessed the effect of capsaicin treatment on the expression of NAPE-PLD and TRPV1 relative to the expression of GAPDH. | |||||||||||||||
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However, assuming that the TRPV1 mRNA we detected in our cultures following the capsaicin treatment, was expressed in neurons, which, in spite of their TRPV1 expression, were not responsive to capsaicin, or alternatively, they were responsive to capsaicin but resistant to the subsequent excitotoxicity, it is tempting to propose that TRPV1 and NAPE-PLD could be co-expressed to a high degree, in primary sensory neurons. | |||||||||||||||
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In these experiments we assessed the effect of capsaicin treatment on the expression of NAPE-PLD and TRPV1 relative to the expression of GAPDH. | |||||||||||||||
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This study used real-time PCR to quantitatively track changes in TRPV1-4 mRNA expression in the spiral, vestibular, and trigeminal ganglia and the kidney from kanamycin (KM)-treated mice. | |||||||||||||||
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increases TRPV1 expression through TNF-? | |||||||||||||||
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Therefore, we examined whether a similar signal transduction pathway is involved in the regulation of TRPV1 responses through EP1. | |||||||||||||||
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