INT125191

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.54
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neuronal 4
DRG 2
kidney 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 201 99.78 Very High Very High Very High
dorsal root ganglion 71 99.20 Very High Very High Very High
trigeminal ganglion 151 92.32 High High
vanilloid receptor subtype 1 1 91.48 High High
Inflammatory mediators 9 91.04 High High
agonist 30 90.00 High High
Nerve growth factor 3 88.24 High High
Pain 60 88.04 High High
Sciatic nerve 16 85.36 High High
member 8 2 81.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 212 99.78 Very High Very High Very High
Cold Sores 136 99.64 Very High Very High Very High
Ganglion Cysts 265 99.20 Very High Very High Very High
Nervous System Injury 6 93.44 High High
Pain 74 88.04 High High
Injury 11 86.56 High High
Nociception 31 81.48 Quite High
Hyperalgesia 63 74.36 Quite High
Acidosis 2 72.52 Quite High
Cancer 2 52.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A major difference between those studies and the current one is that they were carried out in rat, where the distribution of TRPV1 is quite different than in mouse.
Regulation (different) of Transcription (distribution) of TRPV1
1) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.45 Pain Relevance 0.11
In DRG injected with the HSV-U6shLacZ vector, TRPV1 mRNA levels were essentially unchanged compared to the right DRG.
Neg (unchanged) Regulation (unchanged) of Transcription (levels) of TRPV1 associated with dorsal root ganglion and cold sores
2) Confidence 0.43 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.58 Pain Relevance 0.47
With peripheral inflammation, the mRNA expression of TRPV1 and ASIC3 is increased in dorsal root ganglia (DRG) and sensitizes their responses [15-20].
Regulation (sensitizes) of Transcription (expression) of TRPV1 in DRG associated with inflammation
3) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.22 Pain Relevance 1.06
In addition, in a separate study in our laboratories no change in the number of TRPV1-positive cells following inflammation was observed (B.M.
Neg (no) Regulation (change) of Transcription (number) of TRPV1 associated with inflammation
4) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.44 Pain Relevance 0.17
This study used real-time PCR to quantitatively track changes in TRPV1-4 mRNA expression in the spiral, vestibular, and trigeminal ganglia and the kidney from kanamycin (KM)-treated mice.
Regulation (changes) of Transcription (expression) of TRPV1 in kidney
5) Confidence 0.27 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.06 Pain Relevance 0.23
For real time PCR, the relative mRNA expression of P2X3, P2X2 and TRPV1 in the different samples was normalized to the neuronal ?
Regulation (samples) of Transcription (expression) of TRPV1 in neuronal
6) Confidence 0.26 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.39 Pain Relevance 0.26
For real time PCR, the relative mRNA expression of P2X3, P2X2 and TRPV1 in the different samples was normalized to the neuronal ?
Regulation (normalized) of Transcription (expression) of TRPV1 in neuronal
7) Confidence 0.26 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.39 Pain Relevance 0.31

General Comments

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