INT125209

Context Info Confidence 0.33 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.67 Pain Relevance 0.07

nucleus (Pou4f1, Th) cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th) DNA binding (Pou4f1) cytoplasm (Th)

Anatomy Link Frequency DRG 4 Pou4f1 (Mus musculus) Th (Mus musculus)

Pain Link Frequency Relevance Heat dorsal root ganglion 2 75.00 Pain 2 25.00 nociceptor 2 25.00

Disease Link Frequency Relevance Heat Targeted Disruption 6 94.36 Ganglion Cysts 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The present study suggests that Brn-3a may normally suppress TH expression in many small DRG neurons but activate TH expression in large DRG neurons.

Brn-3a Positive_regulation (activate) of Gene_expression (expression) of TH in DRG

1) Confidence 0.33 Published 2005 Journal Brain Res. Section Abstract Doc Link 15725417 Disease Relevance 0.34 Pain Relevance 0.04

The present study suggests that Brn-3a may normally suppress TH expression in many small DRG neurons but activate TH expression in large DRG neurons.

Brn-3a Positive_regulation (activate) of Gene_expression (expression) of TH in DRG

2) Confidence 0.24 Published 2005 Journal Brain Res. Section Abstract Doc Link 15725417 Disease Relevance 0.34 Pain Relevance 0.04

General Comments

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