INT125227

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.52
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHIT1) extracellular region (CHIT1) carbohydrate metabolic process (CHIT1)
lysosome (CHIT1)
Anatomy Link Frequency
platelet 2
macrophage 1
leukocyte 1
CHIT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 95.76 Very High Very High Very High
Pain 24 79.28 Quite High
Inflammation 6 78.48 Quite High
antagonist 1 58.44 Quite High
abdominal pain 2 45.52 Quite Low
Paresthesia 2 41.28 Quite Low
Central nervous system 10 39.48 Quite Low
peripheral neuropathy 13 29.32 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gauchers Disease 224 99.68 Very High Very High Very High
Disease 48 99.28 Very High Very High Very High
Spontaneous Fractures 19 98.24 Very High Very High Very High
Necrosis 28 96.68 Very High Very High Very High
Disease Progression 5 95.20 Very High Very High Very High
Splenomegaly 10 93.84 High High
Hepatomegaly 7 92.24 High High
Neurological Disease 8 86.44 High High
Thrombocytopenia 13 85.28 High High
Pain 18 79.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chitotriosidase level in serum was pronouncedly increased (11,540 nmol/mg protein/hr) while normal level is under 150 nmol/mg protein/hr.
Positive_regulation (increased) of Chitotriosidase
1) Confidence 0.21 Published 2004 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 15727093 Disease Relevance 0.49 Pain Relevance 0.08
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Positive_regulation (increased) of chitotriosidase in platelet
2) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.27 Pain Relevance 0
Several biomarkers (chitotriosidase, ferritin, angiotensin-converting enzyme (ACE) and tartrate-resistant acid phosphatase (TRAP)) are elevated during GD evolution [9-16].
Positive_regulation (elevated) of chitotriosidase associated with gauchers disease
3) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 1.21 Pain Relevance 0.05
The miglustat monotherapy group had a 33% increase in mean chitotriosidase level compared with both ERT and combined treatment groups, both of which recorded desired stable or decreased levels (Table 1).
Positive_regulation (increase) of chitotriosidase
4) Confidence 0.14 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 0.12 Pain Relevance 0
Mean platelet counts decreased and chitotriosidase level increased.
Positive_regulation (increased) of chitotriosidase in platelet
5) Confidence 0.09 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 0.09 Pain Relevance 0
Chitotriosidase originates from macrophages, and stored lipid is the major inducer.87 Macrophages are also the primary source for another cytokine, CCL18, which has been found to be elevated in GD.88 Both these surrogate markers are not organ specific, although they may reflect overall disease burden, and respond to therapeutic response.89 While the exact contribution of chitotriosidase and CCL18 to the disease pathophysiology remains to be elucidated, the pulmonary, skeletal and immune system involvement in GD may have a closer association with the activation and release of different cytokines from the macrophage-monocyte system.
Positive_regulation (contribution) of chitotriosidase in macrophage associated with gauchers disease, disease and cytokine
6) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 1.06 Pain Relevance 0.19
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Positive_regulation (increased) of chitotriosidase in leukocyte
7) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.27 Pain Relevance 0

General Comments

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