INT125237

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.90
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD40LG) extracellular region (CD40LG) plasma membrane (CD40LG)
Anatomy Link Frequency
CII 4
platelets 3
plasma 2
blood 2
B cells 2
CD40LG (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 18 100.00 Very High Very High Very High
Arthritis 134 99.84 Very High Very High Very High
Multiple sclerosis 51 99.56 Very High Very High Very High
Etanercept 6 95.76 Very High Very High Very High
Infliximab 11 95.20 Very High Very High Very High
Inflammation 92 93.44 High High
rheumatoid arthritis 186 93.32 High High
Demyelination 4 92.88 High High
Pain 11 92.60 High High
Leflunomide 4 89.56 High High
Disease Link Frequency Relevance Heat
Arthritis 149 99.84 Very High Very High Very High
Demyelinating Disease 51 99.56 Very High Very High Very High
Neuromyelitis Optica 65 98.80 Very High Very High Very High
Influenza Virus Infection 33 98.68 Very High Very High Very High
Necrosis 16 97.88 Very High Very High Very High
Cytomegalovirus Infection 12 97.72 Very High Very High Very High
Systemic Lupus Erythematosus 59 93.84 High High
Cicatrix 1 93.68 High High
INFLAMMATION 93 93.44 High High
Targeted Disruption 3 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of whole blood to produce IgM and IgG following stimulation is also strongly inhibited.
Negative_regulation (inhibited) of Gene_expression (produce) of IgM in blood
1) Confidence 0.54 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15728468 Disease Relevance 0.36 Pain Relevance 0.43
Three outcomes demonstrated significant UFP exposure–sex interactions (Figure 3): the numbers of leukocytes and platelets expressing CD62P and those of MP expressing CD40L.
Negative_regulation (numbers) of Gene_expression (expressing) of CD40L in platelets
2) Confidence 0.24 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.30 Pain Relevance 0
The loss of tolerance model due to CD40–CD40L activation signals
Negative_regulation (loss) of Gene_expression (signals) of CD40L associated with tolerance
3) Confidence 0.23 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.85 Pain Relevance 0.45
Immunoglobulin levels, particularly IgM and IgE, were reduced in some belimumab cohorts compared with placebo.
Negative_regulation (reduced) of Gene_expression (levels) of IgM
4) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.35 Pain Relevance 0.04
blocking agents, an increased frequency of anti-dsDNA autoantibodies of the IgM isotypes have also been found in our patients treated with adalimubab [7].
Negative_regulation (frequency) of Gene_expression (autoantibodies) of IgM
5) Confidence 0.14 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.54 Pain Relevance 0.34
IgG, IgM, and products of complement activation are deposited in a perivascular pattern in NMO, suggesting a pathogenic role involving autoantibodies [9].
Negative_regulation (deposited) of Gene_expression (products) of IgM associated with neuromyelitis optica
6) Confidence 0.12 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2904295 Disease Relevance 3.38 Pain Relevance 0.85
These findings correspond with the results reported by Steegmann et al. [24], who described considerable reduction of levels of serum immunoglobulins, including IgM, in patients previously exposed to IFN?
Negative_regulation (reduction) of Gene_expression (levels) of IgM
7) Confidence 0.09 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3004381 Disease Relevance 0.25 Pain Relevance 0
Compared with the normoglycemic patients, patients in both the DM and HG groups displayed higher plasma sCD40L levels by 120 and 82.5%, respectively (Table 1).
Negative_regulation (displayed) of Gene_expression (levels) of sCD40L in plasma
8) Confidence 0.08 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.88 Pain Relevance 0.18
Three outcomes demonstrated significant UFP exposure–sex interactions (Figure 3): the numbers of leukocytes and platelets expressing CD62P and those of MP expressing CD40L.
Negative_regulation (numbers) of in leukocytes Gene_expression (expressing) of CD40L in platelets
9) Confidence 0.08 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.30 Pain Relevance 0
HAART potently reduced SIV-specific Ab and total IgM production when initiated on D7 p.i. but was less efficient when initiated on D14p.i.
Negative_regulation (reduced) of Gene_expression (production) of IgM
10) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.16 Pain Relevance 0
In all study groups, despite the above noted declines, mean IgA, IgG and IgM levels remained within normal limits throughout the study.
Negative_regulation (remained) of Gene_expression (levels) of IgM
11) Confidence 0.07 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2938895 Disease Relevance 0.08 Pain Relevance 0.12
Mean IgA, IgG and IgM levels declined from baseline in all three study groups.
Negative_regulation (declined) of Gene_expression (levels) of IgM
12) Confidence 0.07 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2938895 Disease Relevance 0.07 Pain Relevance 0.08
Notably, this impaired cellular response resulted in a selective reduction of IgM-expressing B cells, whereas the numbers of influenza-specific IgG and IgA cells were not changed in the post-RTX group.
Negative_regulation (reduction) of Gene_expression (expressing) of IgM in B cells associated with influenza virus infection
13) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.39 Pain Relevance 0
It binds to dihydro-orotate dehydrogenase and inhibits de novo pyrimidine biosynthesis, thus blocking B- and T-cell proliferation and also strongly suppresses IgG and IgM antibody production [124] It possesses antiviral properties and can inhibit cytomegalovirus and polyoma virus replication in vitro [125].
Negative_regulation (suppresses) of Gene_expression (production) of IgM in T-cell associated with cytomegalovirus infection
14) Confidence 0.05 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.35 Pain Relevance 0.12
The absence of anti-CII IgM production in CIA-resistant monkeys is highly suggestive of a causal link [27].
Negative_regulation (absence) of Gene_expression (production) of IgM in CII associated with arthritis
15) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 0.87 Pain Relevance 0.39
Second, pre-sensitization of rhesus monkeys with heat-denatured CII not only abrogated the capacity to produce anti-CII IgM, but also induced resistance to CIA [20].
Negative_regulation (abrogated) of Gene_expression (produce) of IgM in CII associated with arthritis
16) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991037 Disease Relevance 0.78 Pain Relevance 0.27

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox