INT125242

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Context Info
Confidence 0.64
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 15.87
Pain Relevance 4.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
medial 1
brain 1
legs 1
RLS (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 2 99.84 Very High Very High Very High
sSRI 5 99.78 Very High Very High Very High
pregabalin 6 99.60 Very High Very High Very High
Dopamine 132 98.48 Very High Very High Very High
antidepressant 8 98.48 Very High Very High Very High
Pain 31 98.36 Very High Very High Very High
Anterior cingulate 2 97.80 Very High Very High Very High
Neuropathic pain 6 97.64 Very High Very High Very High
Osteoarthritis 4 97.40 Very High Very High Very High
opioid receptor 5 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 1047 100.00 Very High Very High Very High
Sleep Disorders 175 100.00 Very High Very High Very High
Disease 84 99.60 Very High Very High Very High
Pain 29 98.36 Very High Very High Very High
Hypertension 8 98.12 Very High Very High Very High
Neuropathic Pain 9 97.64 Very High Very High Very High
Osteoarthritis 4 97.40 Very High Very High Very High
Epilepsy 5 96.80 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 44 96.52 Very High Very High Very High
Migraine With Aura 6 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical efficacy in RLS
Localization (efficacy) of RLS associated with restless legs syndrome
1) Confidence 0.64 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671939 Disease Relevance 0.33 Pain Relevance 0.03
Effects in patients with secondary RLS
Localization (secondary) of RLS associated with restless legs syndrome
2) Confidence 0.63 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 1.89 Pain Relevance 0.22
f) Neurological and physical confounding factors affecting sleep quality: restless legs syndrome (RLS): presence of the four essential diagnostic criteria according to the NIH diagnosis and epidemiology workshop for RLS [21], snoring: as perceived or reported by bed partner (at least 3 nights per week)
Localization (syndrome) of RLS in legs associated with snoring, restless legs syndrome and sleep disorders
3) Confidence 0.63 Published 2008 Journal Head Face Med Section Body Doc Link PMC2292164 Disease Relevance 1.15 Pain Relevance 0
Since RLS consequences on nocturnal rest and psychological status may impair glycemic control in this population, diabetologists and diabetes educators should investigate for the presence of RLS in their patients and treat them.


Spec (investigate) Localization (presence) of RLS
4) Confidence 0.62 Published 2010 Journal Diabetes Educ Section Body Doc Link 20185611 Disease Relevance 0 Pain Relevance 0
We found RLS in 61 of them.
Localization (found) of RLS associated with restless legs syndrome
5) Confidence 0.61 Published 2009 Journal Neurol. Sci. Section Abstract Doc Link 19415438 Disease Relevance 0.99 Pain Relevance 0.16
The aetiology of RLS is only partly understood.
Localization (aetiology) of RLS associated with restless legs syndrome
6) Confidence 0.60 Published 2008 Journal CNS Drugs Section Abstract Doc Link 18484792 Disease Relevance 1.21 Pain Relevance 0.04
This choice is partly based on the potential association between the use of other antidepressants, particularly the selective serotonin reuptake inhibitors (SSRIs), and the appearance of RLS.
Localization (appearance) of RLS associated with antidepressant, restless legs syndrome and ssri
7) Confidence 0.59 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 1.82 Pain Relevance 0.60
However, these observations were found only in PD patients and their relevance to RLS patients is unclear.
Localization (relevance) of RLS associated with restless legs syndrome and disease
8) Confidence 0.49 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671772 Disease Relevance 0.68 Pain Relevance 0.24
The etiology of RLS remains unknown.
Localization (etiology) of RLS associated with restless legs syndrome
9) Confidence 0.48 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671938 Disease Relevance 1.40 Pain Relevance 0.03
This hypothesis is supported by well-known therapeutic response of RLS–PLMS to dopaminergic agents (Lin et al 1998; Ondo 1999), as well as the evidence that ADHD, in some cases, is genetically linked to the dopaminergic system (La Hoste et al 1996; Waldman et al 1998).
Localization (response) of RLS associated with attention deficit hyperactivity disorder and restless legs syndrome
10) Confidence 0.48 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671938 Disease Relevance 1.88 Pain Relevance 0
In a small clinical trial, pregabalin was efficacious in treating primary RLS as well as secondary RLS, and further investigation with randomized, placebo-controlled trials was recommended.30
Localization (treating) of RLS associated with pregabalin and restless legs syndrome
11) Confidence 0.43 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874339 Disease Relevance 0.39 Pain Relevance 1.18
In a small clinical trial, pregabalin was efficacious in treating primary RLS as well as secondary RLS, and further investigation with randomized, placebo-controlled trials was recommended.30
Localization (treating) of RLS associated with pregabalin and restless legs syndrome
12) Confidence 0.43 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874339 Disease Relevance 0.39 Pain Relevance 1.18
CONCLUSIONS: We could not demonstrate a relationship between RLS and WML in the brain MRI of our patients.
Localization (relationship) of RLS in brain
13) Confidence 0.40 Published 2008 Journal Neurologia Section Body Doc Link 18770058 Disease Relevance 0.13 Pain Relevance 0
Our findings suggest that, the more severe the RLS, the greater the release of endogenous opioids within the medial pain system.
Localization (release) of RLS in medial associated with pain, endogenous opioid and restless legs syndrome
14) Confidence 0.38 Published 2005 Journal Brain Section Abstract Doc Link 15728657 Disease Relevance 1.00 Pain Relevance 1.02
However, there were no changes in ESS scores after either ropinirole or placebo. 19 patients completed RLS diaries and the mean rate of RLS was 23% in the placebo group compared to 12% in the treatment group.
Localization (rate) of RLS associated with restless legs syndrome
15) Confidence 0.31 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857615 Disease Relevance 1.14 Pain Relevance 0
Among the associated clinical features of RLS, as stated by the IRLSSG, is a serum ferritin level <50 ?
Localization (features) of RLS associated with restless legs syndrome
16) Confidence 0.18 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 1.44 Pain Relevance 0.29

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