INT125245

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 4.38
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mmp14)
Anatomy Link Frequency
plasma 1
caudate putamen 1
fibroblasts 1
cortex 1
Mmp14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 29 100.00 Very High Very High Very High
fibrosis 4 85.36 High High
ischemia 6 75.00 Quite High
Chronic pancreatitis 1 73.16 Quite High
anesthesia 3 68.60 Quite High
halothane 2 68.16 Quite High
dexamethasone 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 14 99.84 Very High Very High Very High
Necrosis 18 99.36 Very High Very High Very High
Primary Sclerosing Cholangitis 9 97.04 Very High Very High Very High
Bronchopulmonary Dysplasia 61 91.24 High High
Fibrosis 3 85.36 High High
Injury 2 84.60 Quite High
Stroke 2 76.12 Quite High
Brain Hemorrhage 6 75.00 Quite High
Pressure And Volume Under Development 6 75.00 Quite High
Pancreatitis 1 73.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently observed a fourfold increase in MMP14 transcripts in lung fibroblasts during alveolarization [7], while mice lacking this enzyme have a reduced alveolar surface area and enlarged air spaces [8], [9], although this seems partly independent of the ability of MMP14 to activate MMP2 [9].
Positive_regulation (increase) of MMP14 in fibroblasts
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.41 Pain Relevance 0.28
In the antitumor necrosis factor-alpha neutralizing antibody-treated rats, infarct volume was significantly reduced (P=0.014, n=7; respectively), and cerebral specific gravity was dramatically increased in the cortex and caudate putamen (P<0.001, n=7; respectively) in association with a reduction in MMP-9 and membrane type 1-MMP upregulation.
Positive_regulation (upregulation) of membrane type 1-MMP in caudate putamen associated with necrosis and metalloproteinase
2) Confidence 0.07 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15729288 Disease Relevance 1.52 Pain Relevance 0.53
Furthermore, Ihh increased the amount of membrane-type 1 matrix metalloproteinase (MT1-MMP) and altered its localization on the plasma membrane, which plays a stimulatory role in cellular migration.
Positive_regulation (increased) of MT1-MMP in plasma associated with metalloproteinase
3) Confidence 0.03 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.93 Pain Relevance 0.33
In the antitumor necrosis factor-alpha neutralizing antibody-treated rats, infarct volume was significantly reduced (P=0.014, n=7; respectively), and cerebral specific gravity was dramatically increased in the cortex and caudate putamen (P<0.001, n=7; respectively) in association with a reduction in MMP-9 and membrane type 1-MMP upregulation.
Positive_regulation (upregulation) of membrane type 1-MMP in cortex associated with necrosis and metalloproteinase
4) Confidence 0.02 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15729288 Disease Relevance 1.52 Pain Relevance 0.53

General Comments

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