INT125246

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 5.34
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
brain 4
caudate putamen 3
cortex 1
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 39 100.00 Very High Very High Very High
ischemia 41 99.44 Very High Very High Very High
agonist 1 73.04 Quite High
anesthesia 4 71.56 Quite High
halothane 3 71.12 Quite High
antagonist 1 71.00 Quite High
nMDA receptor 42 65.92 Quite High
Inflammation 3 16.88 Low Low
cva 3 14.72 Low Low
Spinal cord 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 36 99.98 Very High Very High Very High
Cancer 16 99.84 Very High Very High Very High
Cv General 4 Under Development 11 99.44 Very High Very High Very High
Necrosis 20 99.36 Very High Very High Very High
Pressure And Volume Under Development 14 96.68 Very High Very High Very High
Cv Unclassified Under Development 12 93.36 High High
Stroke 11 91.64 High High
Apoptosis 21 87.56 High High
Brain Hemorrhage 24 86.56 High High
Targeted Disruption 43 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the antitumor necrosis factor-alpha neutralizing antibody-treated rats, infarct volume was significantly reduced (P=0.014, n=7; respectively), and cerebral specific gravity was dramatically increased in the cortex and caudate putamen (P<0.001, n=7; respectively) in association with a reduction in MMP-9 and membrane type 1-MMP upregulation.
Negative_regulation (reduction) of Positive_regulation (upregulation) of MMP-9 in caudate putamen associated with necrosis and metalloproteinase
1) Confidence 0.27 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15729288 Disease Relevance 1.53 Pain Relevance 0.54
neutralization antibody immediately after reversal of MCAO inhibited upregulation of MMP-9 and membrane type 1-MMP, thereby lowering infarct volume and attenuating ischemic brain edema.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of MMP-9 in brain associated with pressure and volume under development and middle cerebral artery infarction
2) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 1.16 Pain Relevance 0.17
In the antitumor necrosis factor-alpha neutralizing antibody-treated rats, infarct volume was significantly reduced (P=0.014, n=7; respectively), and cerebral specific gravity was dramatically increased in the cortex and caudate putamen (P<0.001, n=7; respectively) in association with a reduction in MMP-9 and membrane type 1-MMP upregulation.
Negative_regulation (reduction) of in cortex Positive_regulation (upregulation) of MMP-9 in caudate putamen associated with necrosis and metalloproteinase
3) Confidence 0.09 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15729288 Disease Relevance 1.53 Pain Relevance 0.54
Paralleling these effects on cerebral ischemia, olmesartan treatment also reduced the reactive upregulation in brain angiotensin II, matrix metalloproteinase-2, matrix metalloproteinase-9, and membrane type 1-matrix metalloproteinase in the ischemic area.
Negative_regulation (reduced) of Positive_regulation (upregulation) of metalloproteinase-9 in brain associated with cv general 4 under development, ischemia and metalloproteinase
4) Confidence 0.09 Published 2005 Journal Neuroscience Section Abstract Doc Link 15963646 Disease Relevance 1.12 Pain Relevance 0.58
The presence of MMP-8 or both MMP-2 and MMP-9-inhibitors during NMDA stimulation did not prevent the loss of extracellular NR1 epitopes (data not shown).
Negative_regulation (prevent) of Positive_regulation (presence) of MMP-9
5) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.27

General Comments

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