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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
Anatomy Link Frequency
spinal cord dorsal horn 2
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 13 99.80 Very High Very High Very High
Spinal cord 1 99.48 Very High Very High Very High
Dorsal horn 1 99.00 Very High Very High Very High
tolerance 6 98.52 Very High Very High Very High
Antinociceptive 1 87.52 High High
Opioid 6 84.52 Quite High
Analgesic 2 78.40 Quite High
antagonist 1 76.24 Quite High
analgesia 1 54.88 Quite High
drug abuse 1 45.44 Quite Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanistically, morphine exposure induced a cyclic AMP and protein kinase A-dependent upregulation of neuronal glucocorticoid receptors (GR) within the spinal cord dorsal horn, which was maintained after discontinuation of morphine administration and significantly enhanced upon a second cycle of morphine exposure.
Positive_regulation (induced) of Positive_regulation (upregulation) of GR in spinal cord dorsal horn associated with dorsal horn, spinal cord and morphine
1) Confidence 0.49 Published 2005 Journal Pain Section Abstract Doc Link 15733634 Disease Relevance 0 Pain Relevance 2.11

General Comments

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