INT125282

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.54
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 26 99.56 Very High Very High Very High
antagonist 39 99.48 Very High Very High Very High
tolerance 15 96.84 Very High Very High Very High
Dorsal horn 2 94.36 High High
Spinal cord 2 93.88 High High
analgesia 2 77.60 Quite High
Antinociceptive 2 76.24 Quite High
Opioid 12 73.24 Quite High
drug abuse 2 68.16 Quite High
Analgesic 4 67.12 Quite High
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Congenital Anomalies 1 81.48 Quite High
Hepatotoxicity 2 75.88 Quite High
Liver Failure 2 74.24 Quite High
Tremor 2 68.28 Quite High
Dizziness 4 67.80 Quite High
Sleep Disorders 1 67.36 Quite High
Manic Depressive Disorder 2 12.36 Low Low
Epilepsy 1 11.16 Low Low
Cancer 131 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prevention of the GR upregulation with GR antisense oligonucleotides as well as inhibition of GR activation with the GR antagonist RU38486 effectively prevented the exacerbated morphine tolerance after subsequent cycles of morphine exposure.
Negative_regulation (inhibition) of Positive_regulation (activation) of GR associated with antagonist, tolerance and morphine
1) Confidence 0.57 Published 2005 Journal Pain Section Abstract Doc Link 15733634 Disease Relevance 0 Pain Relevance 2.14
Prevention of the GR upregulation with GR antisense oligonucleotides as well as inhibition of GR activation with the GR antagonist RU38486 effectively prevented the exacerbated morphine tolerance after subsequent cycles of morphine exposure.
Negative_regulation (Prevention) of Positive_regulation (upregulation) of GR associated with antagonist, tolerance and morphine
2) Confidence 0.42 Published 2005 Journal Pain Section Abstract Doc Link 15733634 Disease Relevance 0 Pain Relevance 2.16
The finding that VPA was an effective inhibitor of HDACs arose from observations that valproic acid was able to relieve transcriptional repression of a peroxisomal proliferation and activation of a glucocorticoid receptor (GR)-PPAR?
Negative_regulation (relieve) of Positive_regulation (activation) of glucocorticoid receptor associated with repression
3) Confidence 0.08 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.54 Pain Relevance 0

General Comments

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