INT125296

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Inpp5k) endoplasmic reticulum (Inpp5k) plasma membrane (Inpp5k)
nucleus (Inpp5k) cytoplasm (Inpp5k)
Inpp5k (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 3 99.32 Very High Very High Very High
antinociception 6 98.08 Very High Very High Very High
Kappa opioid receptor 3 84.56 Quite High
Antinociceptive 2 82.84 Quite High
gABA 1 78.60 Quite High
agonist 5 77.32 Quite High
tail-flick 2 75.00 Quite High
Morphine 1 65.68 Quite High
opioid receptor 1 65.00 Quite High
Analgesic 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of these drugs appear to be specifically due to the blockade of PPs, since L-norokadaone (an analogue of okadaic acid that has no effect on PPs) did not modify clonidine- or baclofen-induced antinociception over the wide range of doses used (0.001-1000 pg/mouse, i.c.v.).
Neg (no) Regulation (effect) of PPs associated with antinociception and clonidine
1) Confidence 0.22 Published 2005 Journal Pain Section Abstract Doc Link 15733647 Disease Relevance 0 Pain Relevance 1.32

General Comments

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