INT125305

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 5.25
Pain Relevance 6.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
spinal cord 1
neutrophil 1
SPANXB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 576 100.00 Very High Very High Very High
Inflammation 212 100.00 Very High Very High Very High
b2 receptor 220 99.80 Very High Very High Very High
antagonist 47 99.56 Very High Very High Very High
cytokine 39 99.38 Very High Very High Very High
Spinal cord 16 99.36 Very High Very High Very High
bradykinin 454 99.16 Very High Very High Very High
B1 receptor 111 98.36 Very High Very High Very High
Pain 122 97.20 Very High Very High Very High
agonist 82 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 216 100.00 Very High Very High Very High
Pain 130 97.20 Very High Very High Very High
Sepsis 1 96.96 Very High Very High Very High
Asthma 91 96.64 Very High Very High Very High
Rhinitis 1 95.96 Very High Very High Very High
Pressure And Volume Under Development 13 95.40 Very High Very High Very High
Diabetes Mellitus 17 94.68 High High
Inflammatory Pain 52 94.44 High High
Cancer 12 94.16 High High
Hepatocellular Cancer 2 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This would pose a plausible explanation to the correlation between the change in gene expression of both receptors even with the up-regulation of B1 and down-regulation of TRPV1.
Regulation (regulation) of B1
1) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.60 Pain Relevance 0.75
This cascade may also contribute to the B1 receptor up-regulation since neutrophil influx has been suggested to contribute to the up-regulation of B1 receptors [15].
Regulation (regulation) of B1 in neutrophil associated with b1 receptor
2) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.65 Pain Relevance 0.54
On the other hand, B1 receptors are induced during the inflammatory processes or at least strongly regulated, except in the spinal cord, where they are constitutively expressed in both rat and man [9].
Regulation (regulated) of B1 in spinal cord associated with inflammation and spinal cord
3) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.60 Pain Relevance 1.04
may contribute to the up-regulation of B1 shown in this study.
Regulation (regulation) of B1
4) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.82 Pain Relevance 0.66
The nicotine effect is mediated by activation of airway neuronal nicotinic receptors which results in a transcriptional up-regulation of kinin B1 and B2 receptors.
Regulation (regulation) of B1 in neuronal associated with nicotine
5) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.08 Pain Relevance 0.31
Effects of nicotine on kinin B1 and B2 receptor-mediated airway relaxations
Regulation (Effects) of B1 associated with nicotine and b2 receptor
6) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.75
induced up-regulation of kinin B1 and B2 receptors in airways [20].
Regulation (regulation) of B1
7) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.13 Pain Relevance 0.35
Effects of nicotine on airway kinin B1 and B2 receptor mRNA and protein expressions
Regulation (Effects) of B1 associated with nicotine and b2 receptor
8) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.45
The presented results show that nicotine up-regulated kinin B1 and B2 receptor-mediated airway contractions, leaving 5-HT, cholinergic and endothelin receptor-mediated contractions completely unaffected.
Regulation (regulated) of B1 associated with nicotine and b2 receptor
9) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.29 Pain Relevance 0.47
We have previously, by using an in vitro model of chronic airway inflammation, demonstrated that cytokines can induce transcriptional up-regulation of kinin B1 and B2 receptors and subsequently increase kinin receptor-mediated contractions [19].
Regulation (regulation) of B1 associated with inflammation and cytokine
10) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.78 Pain Relevance 0.45
The use of mice lacking each receptor gene and various specific peptidic and nonpeptidic antagonists have implicated both B1 and B2 receptors as potential therapeutic targets in several pathophysiological events related to inflammation such as pain, sepsis, allergic asthma, rhinitis, and edema, as well as diabetes and cancer.
Regulation (targets) of B1 associated with pain, pressure and volume under development, diabetes mellitus, sepsis, asthma, rhinitis, inflammation, cancer and antagonist
11) Confidence 0.02 Published 2005 Journal Pharmacol. Rev. Section Abstract Doc Link 15734727 Disease Relevance 0.92 Pain Relevance 0.61
This is similar to the effect of A1, B1 (not shown) and C1 extract observed herein.
Regulation (effect) of B1
12) Confidence 0.02 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0.40 Pain Relevance 0

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