INT125345

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.47
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
dopamine neurons 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 140 100.00 Very High Very High Very High
Cannabinoid 107 100.00 Very High Very High Very High
agonist 99 98.12 Very High Very High Very High
depression 208 94.80 High High
Analgesic 60 93.92 High High
Dopamine 2 93.80 High High
antidepressant 132 92.56 High High
antagonist 26 91.24 High High
fluoxetine 20 87.32 High High
tolerance 56 86.44 High High
Disease Link Frequency Relevance Heat
Depression 226 94.80 High High
Stress 47 85.80 High High
Hypothermia 2 82.88 Quite High
Catalepsy 2 81.84 Quite High
Neurodegenerative Disease 30 67.04 Quite High
Targeted Disruption 28 65.04 Quite High
Generalized Anxiety Disorder 1 61.48 Quite High
Anxiety Disorder 8 54.16 Quite High
Body Weight 5 42.84 Quite Low
Sprains And Strains 3 40.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, methanandamide induced a low to moderate internalization of the CB1R (Fig. 3B).
Positive_regulation (induced) of Localization (internalization) of CB1R
1) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 0.59
The preembedding silver-intensified immunogold method described previously [27] was used for the localization of CB1R in prPFC sections processed for the immunoperoxidase method with either mGluR5 or DGL-?
Positive_regulation (used) of Localization (localization) of CB1R
2) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0 Pain Relevance 0
In an attempt to provide an explanation for these conflicting results, further investigations aimed at evaluating the effect of the increase of CB 1 activation and CB1 receptor blockade under identical experimental conditions and assessing the activation and blockade of CB1 receptors in different animal models of depression should be performed.
Positive_regulation (activation) of Localization (blockade) of CB1 associated with depression
3) Confidence 0.47 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.39 Pain Relevance 0.46
In an attempt to provide an explanation for these conflicting results, further investigations aimed at evaluating the effect of the increase of CB 1 activation and CB1 receptor blockade under identical experimental conditions and assessing the activation and blockade of CB1 receptors in different animal models of depression should be performed.
Positive_regulation (increase) of Localization (blockade) of CB1 associated with depression
4) Confidence 0.47 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.39 Pain Relevance 0.47
Activation of CB1 receptors localized on excitatory presynaptic boutons of prefrontal infralimbic cortical neurons making synapses with BNST excitatory projecting neurons to VTA, inhibits VTA dopamine neurons upon infralimbic cortical stimulation, suggesting a new neuronal circuitry for the actions of cannabinoids [14], [15].
Positive_regulation (Activation) of Localization (localized) of CB1 in dopamine neurons associated with dopamine and cannabinoid
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0.46 Pain Relevance 0.39
Although the basis for this unique pharmacology has not as yet been determined, it is possible that regional specificity of cannabinoid CB1 receptor downregulation and endocannabinoid release induced by repeated dosing with Delta9-tetrahydrocannabinol may play a role.
Positive_regulation (induced) of Localization (release) of cannabinoid CB1 receptor associated with endocannabinoid and cannabinoid
6) Confidence 0.13 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15740725 Disease Relevance 0.23 Pain Relevance 0.54

General Comments

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