INT125356

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.66
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) aging (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
liver 2
brain 2
Cat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 9 98.76 Very High Very High Very High
alcohol 11 97.44 Very High Very High Very High
Dopamine 9 89.20 High High
Inflammation 7 87.28 High High
Serotonin 9 86.88 High High
cva 2 86.24 High High
agonist 1 49.08 Quite Low
antagonist 1 48.16 Quite Low
anesthesia 3 44.00 Quite Low
diabetic neuropathy 8 38.88 Quite Low
Disease Link Frequency Relevance Heat
Body Weight 32 99.96 Very High Very High Very High
Hepatotoxicity 29 99.48 Very High Very High Very High
Injury 48 97.60 Very High Very High Very High
Poisoning 29 88.56 High High
INFLAMMATION 10 87.28 High High
Hemorrhage 2 86.24 High High
Necrosis 6 85.04 High High
Toxicity 2 82.20 Quite High
Cancer 1 76.68 Quite High
Hepatitis 1 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with methanol extract of CQ effectively prevented the decrease in SOD and CAT activities, which may be attributed to the scavenging of radicals by CQ resulting in protection of these enzymes.
Negative_regulation (prevented) of Negative_regulation (decrease) of CAT
1) Confidence 0.42 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991701 Disease Relevance 0.43 Pain Relevance 0.09
Pretreatment with methanol extract of CQ significantly prevented the increase in LPO (P < 0.001) and decrease in GSH (P < 0.05), SOD (P < 0.05), and CAT (P < 0.001).
Negative_regulation (prevented) of Negative_regulation (decrease) of CAT
2) Confidence 0.42 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991701 Disease Relevance 0.45 Pain Relevance 0.08
Orally administered octacosanol (100 mg/kg BW) prevented the decrease in hepatic catalase activity found at a progressed stage of CCl4-induced liver injury almost completely.
Negative_regulation (prevented) of Negative_regulation (decrease) of catalase in liver associated with body weight and injury
3) Confidence 0.20 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.95 Pain Relevance 0.05
The pretreated with EtOAc and BuOH fraction led to an increase in free radical scavenging activity and a decrease in inhibition of lipid peroxidation, both superoxide dismutase and catalase prevent the hepatotoxicity by AAP in the treatment of A. japonica fraction.
Negative_regulation (decrease) of Negative_regulation (inhibition) of catalase associated with paracetamol and hepatotoxicity
4) Confidence 0.18 Published 2004 Journal Phytother Res Section Abstract Doc Link 15742342 Disease Relevance 0.59 Pain Relevance 0.76
Moreover, chronic administration of haloperidol resulted in increased lipid peroxidation, decreased reduced glutathione, superoxide dismutase and catalase levels in different regions of brain which was reversed by pretreatment with curcumin.
Negative_regulation (reversed) of Negative_regulation (decreased) of catalase in brain
5) Confidence 0.08 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2929771 Disease Relevance 0.24 Pain Relevance 0.09

General Comments

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