INT12536

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 1991
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 101
Total Number 103
Disease Relevance 36.37
Pain Relevance 73.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
neurons 9
plasma 5
spinal cord 5
nucleus 4
hippocampus 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 1476 100.00 Very High Very High Very High
Calcitonin gene-related peptide 23 99.98 Very High Very High Very High
nMDA receptor 122 99.90 Very High Very High Very High
Hyperalgesia 34 99.90 Very High Very High Very High
Spinal cord 255 99.84 Very High Very High Very High
Dorsal horn 70 99.84 Very High Very High Very High
spinal dorsal horn 23 99.84 Very High Very High Very High
ischemia 171 99.82 Very High Very High Very High
Glutamate 114 99.82 Very High Very High Very High
antagonist 112 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 72 99.90 Very High Very High Very High
Cv Unclassified Under Development 169 99.82 Very High Very High Very High
Nociception 144 99.80 Very High Very High Very High
Stress 31 99.74 Very High Very High Very High
INFLAMMATION 55 99.72 Very High Very High Very High
Injury 70 99.54 Very High Very High Very High
Diabetes Mellitus 224 99.50 Very High Very High Very High
Targeted Disruption 83 99.48 Very High Very High Very High
Ganglion Cysts 245 99.36 Very High Very High Very High
Hypertrophy 89 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDMA-mediated PKC translocation was long-lasting and remained above control (saline-treated rats) for up to 24 h after injection.
Localization (translocation) of PKC associated with kinase c
1) Confidence 0.80 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9272479 Disease Relevance 0 Pain Relevance 0.66
However, pure uptake inhibitors like fluoxetine, cocaine, and the selective 5-HT2A/2C agonist, DOB, were unable to produce a long-lasting translocation of PKC binding sites in rat cortex.
Localization (translocation) of PKC in cortex associated with kinase c, agonist, cocaine and fluoxetine
2) Confidence 0.80 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9272479 Disease Relevance 0 Pain Relevance 0.83
Fluoxetine, a selective serotonin uptake inhibitor (SSRI) and ketanserin a 5-HT2A antagonist, attenuated PKC translocation by MDMA with differing efficacies; however, both compounds completely prevented the loss of 5-HT uptake sties after multiple doses of MDMA.
Localization (translocation) of PKC associated with kinase c, antagonist, ssri, serotonin and fluoxetine
3) Confidence 0.80 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9272479 Disease Relevance 0 Pain Relevance 0.82
These results suggest that MDMA increases PKC translocation by two interrelated mechanisms that involve 5-HT2A/2C receptors and the 5-HT transporter.
Localization (translocation) of PKC associated with kinase c
4) Confidence 0.80 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9272479 Disease Relevance 0 Pain Relevance 0.76
Modulation of PKC translocation and activation may prove useful for the management of pain and opiate addiction.
Localization (translocation) of PKC associated with addiction, pain, kinase c and opiate
5) Confidence 0.80 Published 1995 Journal Pain Section Abstract Doc Link 7478679 Disease Relevance 0.27 Pain Relevance 1.53
The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons.
Localization (translocation) of PKC in neurons associated with addiction, kinase c, analgesic, tolerance and morphine
6) Confidence 0.80 Published 1995 Journal Pain Section Abstract Doc Link 7478679 Disease Relevance 0.10 Pain Relevance 1.45
In the presence of a physiological concentration of Mg2+ in the extracellular medium, glutamate induces PKC translocation by binding to both N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) excitatory amino acid receptors.
Localization (translocation) of PKC associated with kinase c, glutamate and excitatory amino acid
7) Confidence 0.80 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1649249 Disease Relevance 0 Pain Relevance 0.55
In addition the difference between naloxone-precipitated and spontaneous withdrawal in vivo suggests that in postnatal day 7 rats, morphine exposure produces an early phase of primary afferent sensitization dependent upon PKC translocation, followed by a later phase involving spinal sensitization mediated by PKC gamma.
Localization (translocation) of PKC in spinal associated with kinase c, spinal sensitization, narcan, withdrawal and morphine
8) Confidence 0.80 Published 2004 Journal Pain Section Abstract Doc Link 15275778 Disease Relevance 0.38 Pain Relevance 1.35
NMDA receptor-induced PKC translocation is sodium independent, whereas quisqualate receptor-induced PKC translocation is sodium dependent; none of the agonists is active in the absence of calcium from the extracellular medium.
Localization (translocation) of PKC associated with kinase c, nmda receptor and agonist
9) Confidence 0.80 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1649249 Disease Relevance 0 Pain Relevance 0.74
Muscimol does not modify excitatory amino acid stimulation; however, blockade of gamma-aminobutyric acid(A) receptors by bicuculline greatly enhances glutamate-induced PKC translocation.
Localization (translocation) of PKC associated with kinase c, glutamate and excitatory amino acid
10) Confidence 0.80 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1649249 Disease Relevance 0 Pain Relevance 0.74
In primary cultures of neurons from rat cerebral cortex and neostriatum, excitatory amino acids stimulate the translocation of protein kinase C (PKC) from the cytoplasm to the membrane.
Localization (translocation) of PKC in cerebral cortex associated with kinase c, cerebral cortex and excitatory amino acid
11) Confidence 0.80 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1649249 Disease Relevance 0 Pain Relevance 0.49
Both immunoblotting and immunofluorescence showed that cPKCgamma membrane translocation increased in dorsal horn neurons of propofol-remifentanil-based anesthetized rats, which could be inhibited by systemic lidocaine.
Localization (translocation) of cPKCgamma in neurons associated with ultiva, lidocaine and dorsal horn neuron
12) Confidence 0.80 Published 2009 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 19955894 Disease Relevance 0.44 Pain Relevance 2.39
These results suggested that increased cPKCgamma membrane translocation was involved in remifentanil-induced hyperalgesia, which was inhibited by systemic lidocaine and may contribute to reduced postoperative pain in rats after propofol-remifentanil-based anesthesia.
Localization (translocation) of cPKCgamma associated with anesthesia, hyperalgesia, perioperative pain, ultiva and lidocaine
13) Confidence 0.80 Published 2009 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 19955894 Disease Relevance 0.55 Pain Relevance 2.21
Furthermore, spinal cord levels of membrane-bound PKC reliably increase in CCI rats as a result of translocation of PKC revealed by the [3H]PDBu autoradiographic assay.
Localization (translocation) of PKC in spinal cord associated with spinal cord
14) Confidence 0.80 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8742791 Disease Relevance 0.97 Pain Relevance 1.68
Inhibitors of intracellular PKC translocation and activation block thermal hyperalgesia and spontaneous pain behaviors after CCI and also reduce the elevated spinal cord neural activity in CCI rats.
Localization (translocation) of PKC in neural associated with pain, thermal hyperalgesia, spontaneous pain and spinal cord
15) Confidence 0.80 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8742791 Disease Relevance 1.06 Pain Relevance 1.80
A consequence of NMDA receptor activation is calcium influx, which in turn can result in translocation of PKC from cytosol to membrane.
Localization (translocation) of PKC associated with nmda receptor
16) Confidence 0.80 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8742791 Disease Relevance 1.06 Pain Relevance 1.81
This series of studies has investigated the involvement of the NMDA receptor and the translocation of PKC in the seemingly unrelated phenomena of neuropathic pain and tolerance and dependence to narcotic analgesic drugs.
Localization (translocation) of PKC associated with addiction, analgesic, nmda receptor, tolerance and neuropathic pain
17) Confidence 0.80 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8742791 Disease Relevance 0.59 Pain Relevance 1.19
This work has demonstrated that the NMDA receptor and PKC translocation are importantly involved in neuropathic pain and morphine tolerance or dependence and that these phenomena may be importantly interrelated.
Localization (translocation) of PKC associated with addiction, nmda receptor, tolerance, neuropathic pain and morphine
18) Confidence 0.80 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8742791 Disease Relevance 0.80 Pain Relevance 1.48
Re-exposure to the context also increased binding in the thalamus and area CA1 of the hippocampus. [3H]PDBu binds preferentially to PKC in the membrane and, therefore, these results suggest that stress induces the translocation of PKC from its resting compartments in the cytosol to the membrane.
Localization (translocation) of PKC in hippocampus associated with stress, kinase c, hippocampus and thalamus
19) Confidence 0.79 Published 1997 Journal Brain Res. Section Abstract Doc Link 9098555 Disease Relevance 0.46 Pain Relevance 0.90
Coincident with nociception, both noxious chemical stimulation of the hind paw and chronic constriction injury (CCI) of the sciatic nerve produce an increase in protein kinase C (PKC) translocation in the spinal cord of rats.
Localization (translocation) of PKC in spinal cord associated with nociception, kinase c, eae, injury, sciatic nerve and spinal cord
20) Confidence 0.79 Published 2001 Journal Pain Section Abstract Doc Link 11576741 Disease Relevance 0.59 Pain Relevance 0.87

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox