INT12537

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 36
Total Number 39
Disease Relevance 14.57
Pain Relevance 33.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
spinal cord 8
nucleus 8
neurons 8
plasma 2
myocardium 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 353 100.00 Very High Very High Very High
nMDA receptor 66 100.00 Very High Very High Very High
Glutamate 23 100.00 Very High Very High Very High
ischemia 16 100.00 Very High Very High Very High
Spinal cord 120 99.98 Very High Very High Very High
Morphine 36 99.98 Very High Very High Very High
excitatory amino acid 12 99.98 Very High Very High Very High
Dorsal horn neuron 6 99.84 Very High Very High Very High
Sciatic nerve 10 99.76 Very High Very High Very High
agonist 36 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 20 100.00 Very High Very High Very High
Stress 14 99.98 Very High Very High Very High
Hypoxia 7 99.56 Very High Very High Very High
Injury 25 99.54 Very High Very High Very High
Ganglion Cysts 30 99.36 Very High Very High Very High
Adult Respiratory Distress Syndrome 13 98.94 Very High Very High Very High
Hypotension 4 98.88 Very High Very High Very High
Hyperalgesia 26 98.56 Very High Very High Very High
Neuropathic Pain 48 98.36 Very High Very High Very High
Nociception 42 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDMA-mediated PKC translocation was long-lasting and remained above control (saline-treated rats) for up to 24 h after injection.
Positive_regulation (mediated) of Localization (translocation) of PKC associated with kinase c
1) Confidence 0.70 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9272479 Disease Relevance 0 Pain Relevance 0.66
Muscimol does not modify excitatory amino acid stimulation; however, blockade of gamma-aminobutyric acid(A) receptors by bicuculline greatly enhances glutamate-induced PKC translocation.
Positive_regulation (enhances) of Localization (translocation) of PKC associated with kinase c, glutamate and excitatory amino acid
2) Confidence 0.69 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1649249 Disease Relevance 0 Pain Relevance 0.75
Muscimol does not modify excitatory amino acid stimulation; however, blockade of gamma-aminobutyric acid(A) receptors by bicuculline greatly enhances glutamate-induced PKC translocation.
Positive_regulation (induced) of Localization (translocation) of PKC associated with kinase c, glutamate and excitatory amino acid
3) Confidence 0.69 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1649249 Disease Relevance 0 Pain Relevance 0.74
Both immunoblotting and immunofluorescence showed that cPKCgamma membrane translocation increased in dorsal horn neurons of propofol-remifentanil-based anesthetized rats, which could be inhibited by systemic lidocaine.
Positive_regulation (increased) of Localization (translocation) of cPKCgamma in neurons associated with ultiva, lidocaine and dorsal horn neuron
4) Confidence 0.69 Published 2009 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 19955894 Disease Relevance 0.44 Pain Relevance 2.40
These results suggested that increased cPKCgamma membrane translocation was involved in remifentanil-induced hyperalgesia, which was inhibited by systemic lidocaine and may contribute to reduced postoperative pain in rats after propofol-remifentanil-based anesthesia.
Positive_regulation (increased) of Localization (translocation) of cPKCgamma associated with anesthesia, hyperalgesia, perioperative pain, ultiva and lidocaine
5) Confidence 0.69 Published 2009 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 19955894 Disease Relevance 0.55 Pain Relevance 2.22
Furthermore, spinal cord levels of membrane-bound PKC reliably increase in CCI rats as a result of translocation of PKC revealed by the [3H]PDBu autoradiographic assay.
Positive_regulation (result) of Localization (translocation) of PKC in spinal cord associated with spinal cord
6) Confidence 0.69 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8742791 Disease Relevance 0.97 Pain Relevance 1.69
Re-exposure to the context also increased binding in the thalamus and area CA1 of the hippocampus. [3H]PDBu binds preferentially to PKC in the membrane and, therefore, these results suggest that stress induces the translocation of PKC from its resting compartments in the cytosol to the membrane.
Positive_regulation (induces) of Localization (translocation) of PKC in hippocampus associated with stress, kinase c, hippocampus and thalamus
7) Confidence 0.69 Published 1997 Journal Brain Res. Section Abstract Doc Link 9098555 Disease Relevance 0.47 Pain Relevance 0.90
Noxious stimulus-induced PKC translocation likely depends on glutamate activity at either N-methyl-D-aspartate (NMDA) receptors or group I metabotropic glutamate receptors (mGluR1/5) in the spinal cord dorsal horn.
Positive_regulation (induced) of Localization (translocation) of PKC in spinal cord dorsal horn associated with glutamate, kinase c, glutamate receptor, dorsal horn and spinal cord
8) Confidence 0.69 Published 2001 Journal Pain Section Abstract Doc Link 11576741 Disease Relevance 0.59 Pain Relevance 0.92
Because activation of protein kinase C (PKC) may occur following the activation of glutamate receptors, we determined whether pharmacological inhibition of PKC would attenuate morphine-induced c-Fos expression, and whether acute administration of morphine would induce translocation of PKC.
Spec (whether) Positive_regulation (induce) of Localization (translocation) of PKC associated with kinase c, glutamate receptor and morphine
9) Confidence 0.68 Published 2004 Journal Brain Res. Bull. Section Abstract Doc Link 14709343 Disease Relevance 0 Pain Relevance 1.30
NE treatment induced intranuclear translocation of PKC-betaI in cardiac myocytes at 10 min and increased skeletal alpha-actin and beta-MHC mRNAs in the myocardium at 4-24 h.
Positive_regulation (induced) of Localization (translocation) of PKC in myocardium associated with kinase c
10) Confidence 0.57 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10233047 Disease Relevance 0.29 Pain Relevance 0.38
The results provide both pharmacological and anatomical evidence that persistent pain produced by chemical stimulation with formalin and mechanical hyperalgesia in the hindpaw contralateral to a thermal injury are influenced by the translocation and activation of PKC in spinal cord dorsal horn neurons.
Positive_regulation (activation) of Localization (translocation) of PKC in neurons associated with pain, kinase c, hyperalgesia, lasting pain, injury, dorsal horn neuron and spinal cord
11) Confidence 0.50 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751909 Disease Relevance 0.74 Pain Relevance 0.98
These results suggest that MDMA increases PKC translocation by two interrelated mechanisms that involve 5-HT2A/2C receptors and the 5-HT transporter.
Positive_regulation (increases) of Localization (translocation) of PKC associated with kinase c
12) Confidence 0.50 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9272479 Disease Relevance 0 Pain Relevance 0.76
However, pure uptake inhibitors like fluoxetine, cocaine, and the selective 5-HT2A/2C agonist, DOB, were unable to produce a long-lasting translocation of PKC binding sites in rat cortex.
Neg (unable) Positive_regulation (produce) of Localization (translocation) of PKC in cortex associated with kinase c, agonist, cocaine and fluoxetine
13) Confidence 0.50 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9272479 Disease Relevance 0 Pain Relevance 0.83
These results indicate that the translocation and activation of PKC may be a critical step in the development of opiate tolerance and dependence.
Positive_regulation (activation) of Localization (translocation) of PKC associated with addiction, kinase c, tolerance and opiate
14) Confidence 0.50 Published 1995 Journal Pain Section Abstract Doc Link 7478679 Disease Relevance 0.08 Pain Relevance 1.55
In primary cultures of neurons from rat cerebral cortex and neostriatum, excitatory amino acids stimulate the translocation of protein kinase C (PKC) from the cytoplasm to the membrane.
Positive_regulation (stimulate) of Localization (translocation) of PKC in cerebral cortex associated with kinase c, cerebral cortex and excitatory amino acid
15) Confidence 0.50 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1649249 Disease Relevance 0 Pain Relevance 0.49
Furthermore, spinal cord levels of membrane-bound PKC reliably increase in CCI rats as a result of translocation of PKC revealed by the [3H]PDBu autoradiographic assay.
Positive_regulation (increase) of Localization (translocation) of PKC in spinal cord associated with spinal cord
16) Confidence 0.50 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8742791 Disease Relevance 0.99 Pain Relevance 1.71
This series of studies has investigated the involvement of the NMDA receptor and the translocation of PKC in the seemingly unrelated phenomena of neuropathic pain and tolerance and dependence to narcotic analgesic drugs.
Spec (investigated) Positive_regulation (involvement) of Localization (translocation) of PKC associated with addiction, analgesic, nmda receptor, tolerance and neuropathic pain
17) Confidence 0.50 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8742791 Disease Relevance 0.59 Pain Relevance 1.19
Coincident with nociception, both noxious chemical stimulation of the hind paw and chronic constriction injury (CCI) of the sciatic nerve produce an increase in protein kinase C (PKC) translocation in the spinal cord of rats.
Positive_regulation (increase) of Localization (translocation) of PKC in spinal cord associated with nociception, kinase c, eae, injury, sciatic nerve and spinal cord
18) Confidence 0.50 Published 2001 Journal Pain Section Abstract Doc Link 11576741 Disease Relevance 0.59 Pain Relevance 0.87
In contrast, formalin-induced gammaPKC translocation was observed only in postnatal day 21 rats.
Positive_regulation (formalin-induced) of Localization (translocation) of gammaPKC
19) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14762097 Disease Relevance 0.46 Pain Relevance 0.71
Hypothesis 2: Gene expression of key prostaglandin biosynthetic/metabolizing enzymesin PKC?
Positive_regulation (enzymesin) of Localization (metabolizing) of PKC associated with kinase c
20) Confidence 0.49 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.36

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