INT125377

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.59
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Antiemetics 1 99.78 Very High Very High Very High
Buprenorphine 19 99.48 Very High Very High Very High
Bioavailability 6 99.48 Very High Very High Very High
Analgesic 2 99.44 Very High Very High Very High
methadone 8 98.72 Very High Very High Very High
antidepressant 5 98.58 Very High Very High Very High
Opioid 2 97.32 Very High Very High Very High
Inflammation 3 77.76 Quite High
Morphine 1 72.12 Quite High
cINOD 1 27.76 Quite Low
Disease Link Frequency Relevance Heat
Vomiting 1 99.78 Very High Very High Very High
Disease 169 98.08 Very High Very High Very High
Pressure And Volume Under Development 2 96.16 Very High Very High Very High
INFLAMMATION 4 77.76 Quite High
Cognitive Disorder 55 5.00 Very Low Very Low Very Low
Dementia 34 5.00 Very Low Very Low Very Low
Pre-eclampsia 33 5.00 Very Low Very Low Very Low
Vascular Dementia 16 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 14 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs.
Localization (secretion) of P450 associated with methadone and bioavailability
1) Confidence 0.78 Published 2005 Journal J. Vet. Pharmacol. Ther. Section Title Doc Link 16207309 Disease Relevance 0 Pain Relevance 0.82
In this work, koninginins A, E and F (KonA, KonE and KonF, respectivamente) isolated from Trichoderma koningii had their capabilities of inhibiting edema-inducing, myotoxic and enzymatic activities of the total venom of Bothrops jararacussu (jararacu├žu) snake analyzed, as well as one of its homolog forms of phospholipases A(2) (bjPLA(2)-group IIB) and human secreted PLA(2) protein fusion (hsPLA(2)-group IIA).
Localization (secreted) of IIB associated with pressure and volume under development
2) Confidence 0.73 Published 2008 Journal Toxicon Section Abstract Doc Link 17983638 Disease Relevance 0.17 Pain Relevance 0.04
Individual contribution of P450 isoforms in BUP metabolism as well as Nor-BUP production was evaluated using chemical inhibition experiments, as well as the relative activity factor approach.
Localization (contribution) of P450 associated with buprenorphine
3) Confidence 0.45 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.17
Of particular interest are the potential interactions of cholinesterase inhibitors with other drugs of current use in patients with AD, such as antidepressants, neuroleptics, antiarrhythmics, analgesics, and antiemetics which are metabolized by the cytochrome P450 CYP2D6 enzyme (Bernard et al 2006).
Localization (metabolized) of P450 associated with antidepressant, analgesic, disease and antiemetics
4) Confidence 0.17 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.41 Pain Relevance 0.20
It is mobilized by phospholipases, especially cytoplasmatic phospholipase A2, and is metabolized by constitutive cyclooxygenase (COX-1) and inducible COX-2 into prostaglandins and related compounds, by lipooxygenase into leukotrienes and by p450 into epoxieicosanoid acids[10].
Localization (metabolized) of p450
5) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0 Pain Relevance 0

General Comments

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