INT125379

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 0
Pain Relevance 8.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
3A5 1
syncytiotrophoblast 1
COMMD3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 111 100.00 Very High Very High Very High
Morphine 3 69.76 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The glucuronidation of BUP and Nor-BUP was examined using human liver microsomes (HLMs) and heterologously expressed UGTs.
Gene_expression (expressed) of BUP in liver associated with buprenorphine
1) Confidence 0.49 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 19841060 Disease Relevance 0 Pain Relevance 0.84
Among the six hepatic UGT isoforms tested, UGT1A1, UGT1A3, and UGT2B7 metabolized BUP and Nor-BUP.
Neg (Nor) Gene_expression (metabolized) of BUP associated with buprenorphine
2) Confidence 0.49 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 19841060 Disease Relevance 0 Pain Relevance 0.99
Nor-BUP glucuronidation involved predominantly UGT1A3 (approximately 63%) and UGT1A1 (34%), whereas UGT2B7 had only a minor role.
Gene_expression (glucuronidation) of BUP associated with buprenorphine
3) Confidence 0.43 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 19841060 Disease Relevance 0 Pain Relevance 0.99
Among the six hepatic UGT isoforms tested, UGT1A1, UGT1A3, and UGT2B7 metabolized BUP and Nor-BUP.
Neg (Nor) Gene_expression (metabolized) of BUP associated with buprenorphine
4) Confidence 0.43 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 19841060 Disease Relevance 0 Pain Relevance 1.00
The addition of HSA to the perfusion medium affected only the second step of BUP transfer, but AAG affected both steps.
Gene_expression (transfer) of BUP
5) Confidence 0.27 Published 2009 Journal J. Matern. Fetal. Neonatal. Med. Section Body Doc Link 19544152 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: The aim of this investigation is to determine the effect of human serum albumin (HSA) and alpha-acid glycoprotein (AAG) on buprenorphine (BUP) transplacental transfer and distribution.
Gene_expression (transfer) of BUP associated with buprenorphine
6) Confidence 0.27 Published 2009 Journal J. Matern. Fetal. Neonatal. Med. Section Abstract Doc Link 19544152 Disease Relevance 0 Pain Relevance 0.17
RESULTS: Transplacental transfer of BUP, in absence of plasma proteins, is a two-step process: the first is its uptake by the syncytiotrophoblast from the maternal circuit, and the second is its transfer/release from the tissue to the fetal circuit.
Gene_expression (transfer) of BUP in syncytiotrophoblast
7) Confidence 0.27 Published 2009 Journal J. Matern. Fetal. Neonatal. Med. Section Body Doc Link 19544152 Disease Relevance 0 Pain Relevance 0
Individual contribution of P450 isoforms in BUP metabolism as well as Nor-BUP production was evaluated using chemical inhibition experiments, as well as the relative activity factor approach.
Gene_expression (production) of Nor-BUP associated with buprenorphine
8) Confidence 0.24 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.27
Among the 13 P450 isoforms tested, CYP 3A4, 2C8, 3A5, and 3A7 produced Nor-BUP.
Gene_expression (produced) of Nor-BUP in 3A5 associated with buprenorphine
9) Confidence 0.24 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.45
Based on the results of chemical inhibition, CYP 3A4 accounts for about 65% of Nor-BUP production and CYP 2C8 for about 30%.
Gene_expression (production) of Nor-BUP associated with buprenorphine
10) Confidence 0.24 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.46

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