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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.47

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Anatomy Link Frequency
syncytiotrophoblast 2
COMMD3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 21 100.00 Very High Very High Very High
Morphine 1 56.32 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Transplacental transfer of BUP, in absence of plasma proteins, is a two-step process: the first is its uptake by the syncytiotrophoblast from the maternal circuit, and the second is its transfer/release from the tissue to the fetal circuit.
Positive_regulation (transfer) of Gene_expression (transfer) of BUP in syncytiotrophoblast
1) Confidence 0.21 Published 2009 Journal J. Matern. Fetal. Neonatal. Med. Section Body Doc Link 19544152 Disease Relevance 0 Pain Relevance 0
Based on the results of chemical inhibition, CYP 3A4 accounts for about 65% of Nor-BUP production and CYP 2C8 for about 30%.
Positive_regulation (accounts) of Gene_expression (production) of Nor-BUP associated with buprenorphine
2) Confidence 0.18 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.47

General Comments

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