INT125380

Context Info Confidence 0.21 First Reported 2005 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 1.47

Anatomy Link Frequency syncytiotrophoblast 2 COMMD3 (Homo sapiens)

Pain Link Frequency Relevance Heat Buprenorphine 21 100.00 Morphine 1 56.32

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS: Transplacental transfer of BUP, in absence of plasma proteins, is a two-step process: the first is its uptake by the syncytiotrophoblast from the maternal circuit, and the second is its transfer/release from the tissue to the fetal circuit.

Positive_regulation (transfer) of Gene_expression (transfer) of BUP in syncytiotrophoblast

1) Confidence 0.21 Published 2009 Journal J. Matern. Fetal. Neonatal. Med. Section Body Doc Link 19544152 Disease Relevance 0 Pain Relevance 0

Based on the results of chemical inhibition, CYP 3A4 accounts for about 65% of Nor-BUP production and CYP 2C8 for about 30%.

Positive_regulation (accounts) of Gene_expression (production) of Nor-BUP associated with buprenorphine

2) Confidence 0.18 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.47

General Comments

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