INT125392

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 7.20
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mefv) nucleus (Mefv) intracellular (Mefv)
cytoplasm (Mefv)
Anatomy Link Frequency
covering 1
Mefv (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 164 96.96 Very High Very High Very High
abdominal pain 3 95.36 Very High Very High Very High
Arthritis 6 94.28 High High
Inflammation 53 89.76 High High
Pain 4 85.12 High High
rheumatoid arthritis 3 68.40 Quite High
cytokine 1 25.00 Low Low
Inflammatory response 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Disease 223 100.00 Very High Very High Very High
Familial Mediterranean Fever 70 100.00 Very High Very High Very High
Fever 41 100.00 Very High Very High Very High
Syndrome 3 99.92 Very High Very High Very High
Amyloidosis 78 99.64 Very High Very High Very High
Inflammatory Bowel Disease 238 98.76 Very High Very High Very High
Peritonitis 1 96.00 Very High Very High Very High
Abdominal Pain 3 95.36 Very High Very High Very High
Pleurisy 2 94.72 High High
Arthritis 2 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The analysis of Belgian CD trios revealed only nominally significant associations with the major alleles (i.e. allele frequency in controls >50%) of four SNPs, three of which are located in the haplotype block encompassing the region covering the MEFV promoter to intron 2 and its 5?
Regulation (intron) of MEFV in covering associated with crohn's disease
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.53 Pain Relevance 0.16
We conclude that two of the key regulators of the inflammasomes, NLRP3 and MEFV, do not seem to contribute to UC susceptibility.
Regulation (regulators) of MEFV associated with inflammatory bowel disease
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.34 Pain Relevance 0.43
In parallel, the M694V allelic frequency was significantly higher and the V726A allelic frequency significantly lower in the group with amyloidosis, compared to the control FMF group (p < 0.001).
Regulation (control) of FMF associated with amyloidosis and familial mediterranean fever
3) Confidence 0.26 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356915 Disease Relevance 1.91 Pain Relevance 0.03
FMF is predominantly affecting people of Mediterranean descent and clinically characterized by intermittent attacks of fever with peritonitis and abdominal pain, pleuritis, arthritis, or erysipelas-like rashes.
Spec (like) Regulation (affecting) of FMF associated with skin infection, abdominal pain, peritonitis, pleurisy, fever and arthritis
4) Confidence 0.08 Published 2009 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 19033264 Disease Relevance 2.33 Pain Relevance 0.31
Familial Mediterranean Fever (FMF), also known as paroxysmal polyserositis, is an autosomal recessive disease affecting mainly Mediterranean populations (Jews, Armenians, Arabs, Turks).
Regulation (affecting) of FMF associated with familial mediterranean fever and disease
5) Confidence 0.02 Published 2004 Journal Sante Section Abstract Doc Link 15745878 Disease Relevance 1.09 Pain Relevance 0.13

General Comments

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