INT125396

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 5.14
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
sciatic nerve 4
smooth muscle 2
mast cell 2
paw 1
spinal cord 1
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
B1 receptor 26 100.00 Very High Very High Very High
Sciatic nerve 9 99.80 Very High Very High Very High
Spinal cord 3 98.40 Very High Very High Very High
Pain 4 98.32 Very High Very High Very High
cytokine 9 97.48 Very High Very High Very High
allodynia 9 96.56 Very High Very High Very High
bradykinin 54 96.24 Very High Very High Very High
Inflammation 53 95.68 Very High Very High Very High
ischemia 13 93.72 High High
antagonist 20 93.68 High High
Disease Link Frequency Relevance Heat
Pain 7 98.32 Very High Very High Very High
Pressure And Volume Under Development 4 97.96 Very High Very High Very High
Neuropathic Pain 24 96.56 Very High Very High Very High
INFLAMMATION 58 95.68 Very High Very High Very High
Coronary Artery Disease 1 93.72 High High
Hyperalgesia 6 90.68 High High
Myocardial Infarction 1 87.52 High High
Targeted Disruption 16 85.52 High High
Nicotine Addiction 12 84.24 Quite High
Cv Unclassified Under Development 12 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Partial sciatic nerve ligation induced an upregulation in B1 receptor mRNA in ipsilateral paw, sciatic nerve, and spinal cord of wild-type mice.
Positive_regulation (induced) of Positive_regulation (upregulation) of B1 receptor mRNA in sciatic nerve associated with b1 receptor, sciatic nerve and spinal cord
1) Confidence 0.69 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15745967 Disease Relevance 1.02 Pain Relevance 1.32
Moreover, it has been demonstrated that B1R activation can enhance the release of prostaglandins [16], mast cell mediators [15], cytokines, mainly IL-1?
Positive_regulation (enhance) of Positive_regulation (activation) of B1R in mast cell associated with cytokine
2) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.64 Pain Relevance 0.75
Partial sciatic nerve ligation induced an upregulation in B1 receptor mRNA in ipsilateral paw, sciatic nerve, and spinal cord of wild-type mice.
Positive_regulation (induced) of in spinal cord Positive_regulation (upregulation) of B1 receptor mRNA in sciatic nerve associated with b1 receptor, sciatic nerve and spinal cord
3) Confidence 0.23 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15745967 Disease Relevance 1.02 Pain Relevance 1.32
Partial sciatic nerve ligation induced an upregulation in B1 receptor mRNA in ipsilateral paw, sciatic nerve, and spinal cord of wild-type mice.
Positive_regulation (induced) of in paw Positive_regulation (upregulation) of B1 receptor mRNA in sciatic nerve associated with b1 receptor, sciatic nerve and spinal cord
4) Confidence 0.23 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15745967 Disease Relevance 1.02 Pain Relevance 1.32
Stimulation of kinin B1 and B2 receptors on the airway smooth muscle directly activates the inositol 1,4,5-trisphosphate (IP3) pathway increasing intracellular Ca2+ levels which subsequently activates the cellular contractile machinery [18].
Positive_regulation (activates) of Positive_regulation (Stimulation) of kinin in smooth muscle
5) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.43 Pain Relevance 0.50

General Comments

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