INT125407

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 9
Disease Relevance 0.72
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PTPRM) cell adhesion (PTPRM) plasma membrane (OPRL1)
cytoplasm (PTPRM) signal transducer activity (OPRL1)
Anatomy Link Frequency
brain 5
tails 4
OPRL1 (Homo sapiens)
PTPRM (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 36 94.36 High High
Enkephalin 9 93.76 High High
Potency 18 91.52 High High
opioid receptor 27 90.68 High High
analgesia 9 88.52 High High
orphanin 9 84.00 Quite High
mu opioid receptor 9 75.00 Quite High
agonist 9 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 9 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-immunoprecipitation experiments demonstrate that ORL1 dimerizes with muR and that intracellular C-terminal tails of ORL1 and muR are required for the formation of ORL1/muR heterodimer.
ORL1 Binding (formation) of muR in tails
1) Confidence 0.03 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.08 Pain Relevance 0.53
Co-immunoprecipitation experiments demonstrate that ORL1 dimerizes with muR and that intracellular C-terminal tails of ORL1 and muR are required for the formation of ORL1/muR heterodimer.
ORL1 Binding (heterodimer) of muR in tails
2) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.08 Pain Relevance 0.54
Co-immunoprecipitation experiments demonstrate that ORL1 dimerizes with muR and that intracellular C-terminal tails of ORL1 and muR are required for the formation of ORL1/muR heterodimer.
ORL1 Binding (dimerizes) of muR in tails
3) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.08 Pain Relevance 0.53
Thus, it is hypothesized that ORL1 and muR interact to form the heterodimer and that ORL1/muR heterodimerization may be one molecular basis for ORL1-mediated antiopioid effects in the brain.
ORL1 Binding (interact) of muR in brain
4) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.09 Pain Relevance 0.49
These results provide the evidence that ORL1/muR heterodimerization and the resulting impairment of mu receptor-activated signaling pathways may contribute to ORL1-mediated antiopioid effects in the brain.
ORL1 Binding (heterodimerization) of muR in brain
5) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.06 Pain Relevance 0.49
Thus, it is hypothesized that ORL1 and muR interact to form the heterodimer and that ORL1/muR heterodimerization may be one molecular basis for ORL1-mediated antiopioid effects in the brain.
ORL1 Binding (heterodimerization) of muR in brain
6) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.09 Pain Relevance 0.54
Co-immunoprecipitation experiments demonstrate that ORL1 dimerizes with muR and that intracellular C-terminal tails of ORL1 and muR are required for the formation of ORL1/muR heterodimer.
ORL1 Binding (formation) of muR in tails
7) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.08 Pain Relevance 0.53
Thus, it is hypothesized that ORL1 and muR interact to form the heterodimer and that ORL1/muR heterodimerization may be one molecular basis for ORL1-mediated antiopioid effects in the brain.
ORL1 Binding (heterodimerization) of muR in brain
8) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.09 Pain Relevance 0.54
These results provide the evidence that ORL1/muR heterodimerization and the resulting impairment of mu receptor-activated signaling pathways may contribute to ORL1-mediated antiopioid effects in the brain.
ORL1 Binding (heterodimerization) of muR in brain
9) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.06 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox