INT125411

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 18.55
Pain Relevance 19.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
spinal 6
astrocyte 5
Spinal cord 4
dorsal horn 4
neurons 4
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 95 100.00 Very High Very High Very High
Pain 90 100.00 Very High Very High Very High
noradrenaline 33 100.00 Very High Very High Very High
Hyperalgesia 21 100.00 Very High Very High Very High
Arthritis 76 99.98 Very High Very High Very High
Etanercept 24 99.98 Very High Very High Very High
Neuropathic pain 114 99.96 Very High Very High Very High
Perioperative pain 84 99.92 Very High Very High Very High
Spinal nerve ligature 20 99.92 Very High Very High Very High
allodynia 111 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 138 100.00 Very High Very High Very High
Ganglion Cysts 104 100.00 Very High Very High Very High
Hyperalgesia 31 100.00 Very High Very High Very High
Experimental Arthritis 50 99.98 Very High Very High Very High
Neuropathic Pain 256 99.96 Very High Very High Very High
Post Operative Pain 88 99.92 Very High Very High Very High
Cancer Pain 10 99.80 Very High Very High Very High
INFLAMMATION 330 98.88 Very High Very High Very High
Injury 84 98.86 Very High Very High Very High
Primary Sclerosing Cholangitis 11 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the p55 TNF soluble receptor (sTNFRs) by HSV-mediated gene transfer resulted in reduced pain behavior and a decreased number of ED1-positive cells, as well as decreased phosphorylation of the p38 MAP kinase (p-p38) and diminished expression of mTNF-alpha in the dorsal horn.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of p38 in dorsal horn
1) Confidence 0.57 Published 2006 Journal Ann. Neurol. Section Body Doc Link 16634039 Disease Relevance 0.13 Pain Relevance 0
Furthermore, etanercept blocked spinal p38 phosphorylation, placing the cytokine upstream of the MAP kinase in the neural regulation of inflammation.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of p38 in neural associated with inflammation, etanercept and cytokine
2) Confidence 0.55 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.92 Pain Relevance 1.12
Under these conditions, NA inhibited only the ATP-stimulated phosphorylation of p38 in a time (30-60 min)- and dose (10-100 microM)-dependent manner, but did not affect those of ERK, JNK, or MKK3/6.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of p38 associated with noradrenaline
3) Confidence 0.51 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0 Pain Relevance 0.39
Furthermore, preincubation with either actinomycin D or cyclohexamide, general inhibitors of transcription or protein synthesis, respectively, almost completely blocked the inhibitory action of NA on the ATP-stimulated phosphorylation of p38.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of p38 associated with noradrenaline
4) Confidence 0.51 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0.18 Pain Relevance 0.43
Both pharmacological blockades by intrathecal administration of P2Y(12) antagonist and antisense knockdown of P2Y(12) expression suppressed the development of pain behaviors and the phosphorylation of p38 MAPK in spinal microglia after PSNL.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of p38 in microglia associated with pain, antagonist and intrathecal
5) Confidence 0.48 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337420 Disease Relevance 0.96 Pain Relevance 1.00
We found that prolonged knockdown of TLR4 during the 3-day administration of TLR4 small interfering RNA (siRNA; 2 microg/rat/day, i.t.) could attenuate hyperalgesia developed by Walker 256 cells' inoculation and decrease the phosphorylation of p38 as well as the increase of IL-1beta and TNF-alpha expression.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of p38 associated with hyperalgesia
6) Confidence 0.48 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.08 Pain Relevance 1.05
Both intraplantar formalin and intrathecal substance P produced an increase in spinal p38 phosphorylation and this phosphorylation (activation) was prevented when spinal p38beta, but not p38alpha, was down-regulated.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of p38 in spinal associated with substance p and intrathecal
7) Confidence 0.43 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748168 Disease Relevance 0.39 Pain Relevance 0.73
Furthermore, 1400W at a dose that suppressed formalin-induced flinching behavior also blocked formalin-evoked p38 phosphorylation (activation) in the spinal cord, while nNOS inhibitor-I displayed no activity.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of p38 in spinal cord associated with spinal cord
8) Confidence 0.42 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17561811 Disease Relevance 0.63 Pain Relevance 0.54
Expression of the p55 TNF soluble receptor (sTNFRs) by HSV-mediated gene transfer resulted in reduced pain behavior and a decreased number of ED1-positive cells, as well as decreased phosphorylation of the p38 MAP kinase (p-p38) and diminished expression of mTNF-alpha in the dorsal horn.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of p38 in dorsal horn
9) Confidence 0.41 Published 2006 Journal Ann. Neurol. Section Body Doc Link 16634039 Disease Relevance 0.13 Pain Relevance 0
in the nervous system because IT etanercept (a TNF inhibitor) given during adjuvant arthritis blocked spinal p38 phosphorylation and reduced clinical signs of adjuvant arthritis.


Negative_regulation (blocked) of Phosphorylation (phosphorylation) of p38 in nervous system associated with experimental arthritis, etanercept, arthritis and intrathecal
10) Confidence 0.41 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1560929 Disease Relevance 1.26 Pain Relevance 0.96
Phosphorylated p38 levels then decreased, with a second peak at 10 days.
Negative_regulation (decreased) of Phosphorylation (Phosphorylated) of p38
11) Confidence 0.40 Published 2006 Journal J Pain Section Abstract Doc Link 16632323 Disease Relevance 0.64 Pain Relevance 1.24
PERSPECTIVE: Age and modifications to spinal nerve ligation, a common model of neuropathic pain, influence spinal p38 phosphorylation and allodynia.
Negative_regulation (influence) of Phosphorylation (hosphorylation ) of p38 in spinal nerve associated with allodynia, spinal nerve ligature and neuropathic pain
12) Confidence 0.40 Published 2006 Journal J Pain Section Abstract Doc Link 16632323 Disease Relevance 0.73 Pain Relevance 1.18
Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta-adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia.
Negative_regulation (reduces) of Phosphorylation (phosphorylation) of p38 in spinal associated with noradrenaline
13) Confidence 0.37 Published 2009 Journal Neurochem. Int. Section Title Doc Link 19524113 Disease Relevance 0 Pain Relevance 0.55
On the other hand, a 3-day administration [4 microg/rat/day, intrathecally (i.t.)] of 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB203580), an inhibitor of p38MAPK, could suppress tactile allodynia and spontaneous pain of the bone cancer pain rats and decrease the phosphorylation of p38 as well as the expression of IL-1beta and TNF-alpha.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of p38 associated with pain, brush evoked pain, cancer pain and spontaneous pain
14) Confidence 0.35 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.29 Pain Relevance 1.05
Continuous intrathecal infusion of the FGFR1 inhibitor, 3-[3-(2-carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone, reduced p38 MAPK phosphorylation in the DRG and pain-related behaviors in the partial sciatic nerve model rat without affecting on the activation of spinal glia cells (microglia and astrocyte).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of p38 in astrocyte associated with pain, dorsal root ganglion, sciatic nerve and intrathecal
15) Confidence 0.33 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905520 Disease Relevance 0.82 Pain Relevance 0.80
In vitro, hypertonicity interfered with fMLP-induced p38 mitogen activated kinase (MAPK) phosphorylation and opioid peptide release from neutrophils.
Negative_regulation (interfered) of Phosphorylation (phosphorylation) of p38 in neutrophils associated with opioid
16) Confidence 0.32 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 19233260 Disease Relevance 0.70 Pain Relevance 1.50
Local release of the soluble p55 TNF receptor, achieved by herpes simplex virus vector-based gene transfer to dorsal root ganglion, resulted in a reduction of mTNFalpha and concomitant reductions in interleukin-1beta and phosphorylated p38 MAP kinase.
Negative_regulation (reductions) of Phosphorylation (phosphorylated) of p38 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and herpes simplex virus
17) Confidence 0.27 Published 2007 Journal Gene Ther. Section Abstract Doc Link 17443214 Disease Relevance 1.07 Pain Relevance 1.09
In a model of nerve-injury-induced chronic pain, propentofylline has been shown to inhibit hyperalgesia and associated p38 phosphorylation in glial cells [32], [33].
Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of p38 in glial cells associated with hyperalgesia, lasting pain and injury
18) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 1.04 Pain Relevance 0.96
EGCG suppressed these alterations, abolished pressure-induced phosphorylation of p38 MAPK, and suppressed pressure-induced PSC transformation to activated phenotype.
Negative_regulation (abolished) of Phosphorylation (phosphorylation) of p38 associated with primary sclerosing cholangitis
19) Confidence 0.24 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17761838 Disease Relevance 0.32 Pain Relevance 0.17
Thus we proved that curcumin might inhibit the phosphorylation of p38 by activating MKP-1, and eventually reduced the inflammatory response.
Spec (might) Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of p38 associated with inflammatory response
20) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.33 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox