INT125436

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 0.43
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Abpd) cellular_component (Abpd) biological_process (Abpd)
Anatomy Link Frequency
joint 1
Abpd (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 18 88.40 High High
rheumatoid arthritis 160 79.88 Quite High
spinal inflammation 6 50.00 Quite Low
Osteoarthritis 10 40.16 Quite Low
visual analogue scale 10 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 18 88.40 High High
Rheumatoid Arthritis 165 79.88 Quite High
Disease 86 78.08 Quite High
Osteoarthritis 15 52.76 Quite High
Low Back Pain 6 50.00 Quite Low
Obesity 25 17.80 Low Low
Pain 5 5.00 Very Low Very Low Very Low
Arthropathy 5 5.00 Very Low Very Low Very Low
Disease Progression 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: At baseline, patients with AS demonstrated significant elevations in serum levels of CPII, the 846 epitope, and the CPII-to-C2C (CPII:C2C) ratio (but not C2C or C1-2C) compared with normal controls.
Positive_regulation (elevations) of C2C
1) Confidence 0.06 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 15751093 Disease Relevance 0 Pain Relevance 0
RESULTS: At baseline, patients with AS demonstrated significant elevations in serum levels of CPII, the 846 epitope, and the CPII-to-C2C (CPII:C2C) ratio (but not C2C or C1-2C) compared with normal controls.
Positive_regulation (elevations) of C2C
2) Confidence 0.06 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 15751093 Disease Relevance 0 Pain Relevance 0
Also, patients who had a positive rheumatoid factor test at 1 year had significantly higher levels of C2C, of C1,2C, and of CS846-epitope.
Positive_regulation (levels) of C2C
3) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526568 Disease Relevance 0.19 Pain Relevance 0.07
RESULTS: At baseline, patients with AS demonstrated significant elevations in serum levels of CPII, the 846 epitope, and the CPII-to-C2C (CPII:C2C) ratio (but not C2C or C1-2C) compared with normal controls.
Positive_regulation (elevations) of C2C
4) Confidence 0.05 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 15751093 Disease Relevance 0 Pain Relevance 0
An increase in the current C2C value by one standard deviation (for example, by 62 units) was associated with a 5% relative increase in the value in the following year of the radiographic damage score among subjects who have the same current score.
Positive_regulation (increase) of C2C
5) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526568 Disease Relevance 0 Pain Relevance 0
The relative percentage increase of the progression rate of the radiographic damage score per one standard deviation increase in C2C is therefore 21%.
Positive_regulation (increase) of C2C
6) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526568 Disease Relevance 0.07 Pain Relevance 0
Associations of recent biomarkers with progression of erosion or the narrowing score was only apparent for C2C, which was statistically significantly associated with the progression of the joint space narrowing score over the following year (for example, a relative increase of 6.4% in the joint space narrowing score during the next year caused by a one standard deviation increase in the C2C value.


Positive_regulation (increase) of C2C in joint
7) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526568 Disease Relevance 0.09 Pain Relevance 0.04
The relative percentage increase of the progression rate of the radiographic damage score per one standard deviation increase in C2C is therefore 21%.
Positive_regulation (increase) of C2C
8) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526568 Disease Relevance 0.08 Pain Relevance 0

General Comments

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