INT125439

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 6.71
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (NFIB) nucleus (NFIB) intracellular (NFIB)
DNA binding (NFIB)
Anatomy Link Frequency
synovium 1
NFIB (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 76 99.44 Very High Very High Very High
Arthritis 424 99.40 Very High Very High Very High
Inflammation 87 98.98 Very High Very High Very High
Osteoarthritis 8 96.76 Very High Very High Very High
metalloproteinase 169 91.92 High High
headache 4 88.84 High High
Pain 12 88.44 High High
Inflammatory stimuli 5 14.56 Low Low
dexamethasone 28 5.00 Very Low Very Low Very Low
methotrexate 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 49 99.72 Very High Very High Very High
Rheumatoid Arthritis 412 99.40 Very High Very High Very High
INFLAMMATION 102 98.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 18 98.80 Very High Very High Very High
Osteoarthritis 8 96.76 Very High Very High Very High
Pneumonia 48 91.76 High High
Toxicity 2 90.48 High High
Apoptosis 48 89.76 High High
Fatigue 4 89.68 High High
Headache 4 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the serum cytokines examined, only Interleukin (IL)-1beta level was elevated in this case.
Positive_regulation (elevated) of 1beta associated with cytokine
1) Confidence 0.67 Published 2005 Journal Haematologica Section Abstract Doc Link 15753051 Disease Relevance 0.96 Pain Relevance 0.23
As a high level of IL-1beta was detected at the onset of ALI, on day 4 after G-CSF administration, and decreased to below the level of detection on day 11, it is possible in a certain part that IL-1beta was involved in the onset of G-CSF-related ALI in the present case.
Positive_regulation (level) of 1beta associated with adult respiratory distress syndrome
2) Confidence 0.49 Published 2005 Journal Haematologica Section Abstract Doc Link 15753051 Disease Relevance 1.12 Pain Relevance 0.33
Some activated NF-B members such as NFKB1 and RelA were found in the nuclei of cells from synovial tissue in RA patients, whereas these transcript factors were not detected in the nuclei of cells from normal synovial tissues [102].
Positive_regulation (activated) of NF-B associated with arthritis
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.08 Pain Relevance 0.44
Patients with RA present constitutively high serum levels of pre-inflammatory cytokines, including TNF-, IL1 and IL6, which are NF-B target genes, suggesting activation of this pathway in the course of RA disease.
Positive_regulation (activation) of NF-B associated with inflammation, disease, cytokine and arthritis
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.04 Pain Relevance 0.44
Apart from the increased concentration of the active NF-B in synovium, its binding to DNA was found to be much stronger in RA compared to osteoarthritis patients [104].
Positive_regulation (increased) of NF-B in synovium associated with osteoarthritis and arthritis
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.94 Pain Relevance 0.42
The activation of the TLRs signaling pathway can trigger the activation of the MAPK and NF-B pathways.
Positive_regulation (activation) of NF-B
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.85 Pain Relevance 0.19
In line with this, it has been shown in animal models that both stretch during ventilation and stimulation with bacterial antigen, activate nuclear factor B, followed by cytokine release [37].
Positive_regulation (activate) of nuclear factor B associated with cytokine
7) Confidence 0.01 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.72 Pain Relevance 0.47

General Comments

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