INT125442

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.92
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rora) DNA binding (Rora)
Anatomy Link Frequency
neurons 6
adrenal glands 6
spinal 2
cortex 2
Rora (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 228 100.00 Very High Very High Very High
antagonist 32 99.80 Very High Very High Very High
GABAergic 52 95.92 Very High Very High Very High
gABA 48 92.96 High High
Spinal cord 72 91.12 High High
Hippocampus 8 88.96 High High
Action potential 20 87.60 High High
amygdala 4 86.96 High High
anesthesia 4 82.92 Quite High
Dorsal horn 44 81.48 Quite High
Disease Link Frequency Relevance Heat
Repression 4 93.36 High High
Ataxia 28 92.96 High High
Protein Deficiency 4 75.00 Quite High
Targeted Disruption 16 18.56 Low Low
Nociception 28 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of retinoic acid-related orphan receptor alpha (ROR-alpha) was repressed in the cortex and adrenal glands of TTP-deficient mice.
Negative_regulation (repressed) of Gene_expression (expression) of retinoic acid-related orphan receptor alpha in adrenal glands
1) Confidence 0.57 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15753139 Disease Relevance 0.73 Pain Relevance 0.08
The expression of retinoic acid-related orphan receptor alpha (ROR-alpha) was repressed in the cortex and adrenal glands of TTP-deficient mice.
Negative_regulation (repressed) of Gene_expression (expression) of ROR-alpha in adrenal glands
2) Confidence 0.41 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15753139 Disease Relevance 0.73 Pain Relevance 0.08
The expression of retinoic acid-related orphan receptor alpha (ROR-alpha) was repressed in the cortex and adrenal glands of TTP-deficient mice.
Negative_regulation (repressed) of in cortex Gene_expression (expression) of retinoic acid-related orphan receptor alpha in adrenal glands
3) Confidence 0.19 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15753139 Disease Relevance 0.73 Pain Relevance 0.08
The expression of retinoic acid-related orphan receptor alpha (ROR-alpha) was repressed in the cortex and adrenal glands of TTP-deficient mice.
Negative_regulation (repressed) of in cortex Gene_expression (expression) of ROR-alpha in adrenal glands
4) Confidence 0.14 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15753139 Disease Relevance 0.73 Pain Relevance 0.08
To study the relationship between firing patterns and ATPA responsiveness in spinal SG neurons, inward sIPSCs were recorded in the presence of AP5 (50 ?
Negative_regulation (responsiveness) of Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
5) Confidence 0.04 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.51
Tonic activation of GluR5 KARs modulate inhibitory synaptic transmission in SG neurons
Negative_regulation (transmission) of Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
6) Confidence 0.04 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.81
Furthermore, GluR5 antagonist LY293558 inhibited both sIPSC and mIPSC frequencies in spinal SG neurons.
Negative_regulation (inhibited) of Gene_expression (neurons) of SG in spinal associated with substantia gelatinosa and antagonist
7) Confidence 0.04 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.59
M), inward currents could be observed in all SG neurons recorded during the application of ATPA (3 ?
Negative_regulation (recorded) of Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
8) Confidence 0.04 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.31

General Comments

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