INT125444

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 21
Disease Relevance 3.05
Pain Relevance 8.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rora) DNA binding (Rora)
Anatomy Link Frequency
neurons 14
adrenal glands 2
cortex 2
spinal 1
spinal cord 1
Rora (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 969 100.00 Very High Very High Very High
Spinal cord 306 99.68 Very High Very High Very High
GABAergic 221 99.52 Very High Very High Very High
antagonist 136 99.36 Very High Very High Very High
Dorsal horn 187 99.04 Very High Very High Very High
gABA 204 98.80 Very High Very High Very High
Glutamate 51 98.08 Very High Very High Very High
amygdala 17 93.80 High High
Hippocampus 34 92.92 High High
Action potential 85 85.48 High High
Disease Link Frequency Relevance Heat
Repression 4 93.36 High High
Ataxia 28 91.76 High High
Targeted Disruption 68 89.04 High High
Protein Deficiency 4 75.00 Quite High
Epilepsy 17 25.76 Quite Low
Anxiety Disorder 17 24.96 Low Low
Pain 51 23.68 Low Low
Nociception 119 5.00 Very Low Very Low Very Low
Overdose 17 5.00 Very Low Very Low Very Low
Congenital Anomalies 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of retinoic acid-related orphan receptor alpha (ROR-alpha) was repressed in the cortex and adrenal glands of TTP-deficient mice.
Gene_expression (expression) of ROR-alpha in adrenal glands
1) Confidence 0.75 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15753139 Disease Relevance 0.73 Pain Relevance 0.08
The expression of retinoic acid-related orphan receptor alpha (ROR-alpha) was repressed in the cortex and adrenal glands of TTP-deficient mice.
Gene_expression (expression) of retinoic acid-related orphan receptor alpha in adrenal glands
2) Confidence 0.75 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15753139 Disease Relevance 0.72 Pain Relevance 0.08
The expression of retinoic acid-related orphan receptor alpha (ROR-alpha) was repressed in the cortex and adrenal glands of TTP-deficient mice.
Gene_expression (expression) of retinoic acid-related orphan receptor alpha in cortex
3) Confidence 0.26 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15753139 Disease Relevance 0.72 Pain Relevance 0.08
The expression of retinoic acid-related orphan receptor alpha (ROR-alpha) was repressed in the cortex and adrenal glands of TTP-deficient mice.
Gene_expression (expression) of ROR-alpha in cortex
4) Confidence 0.26 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15753139 Disease Relevance 0.73 Pain Relevance 0.08
These results suggest that ATPA significantly facilitated the inhibitory transmission in lamina II of the dorsal horn via the activation of GluR5-containing KARs in SG neurons.
Gene_expression (neurons) of SG in lamina associated with substantia gelatinosa and dorsal horn
5) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.59
Tonic activation of GluR5 KARs modulate inhibitory synaptic transmission in SG neurons
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
6) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.81
To investigate whether presynaptic GluR5 KARs are activated by endogenous glutamate, we examined the effect of bath application of GluR5 antagonist, LY293558, on sIPSCs in spinal SG neurons.
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa, glutamate and antagonist
7) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.68
In SG neurons from GluR5-/- mice, there was no difference in the frequency of sIPSCs compared with that of wide-type SG neurons (GluR5-/-: 0.8 ± 0.1 Hz, n = 5; wide-type: 1.3 ± 0.3 Hz, n = 8, P > 0.05).
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
8) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.41
Mechanism for GluR5 modulation of inhibitory transmission in SG neurons
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
9) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.54
To study the relationship between firing patterns and ATPA responsiveness in spinal SG neurons, inward sIPSCs were recorded in the presence of AP5 (50 ?
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
10) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.50
We further examined the effect of LY293558 on mIPSCs in spinal SG neurons.
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
11) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.06 Pain Relevance 0.28
Furthermore, GluR5 antagonist LY293558 inhibited both sIPSC and mIPSC frequencies in spinal SG neurons.
Gene_expression (neurons) of SG in spinal associated with substantia gelatinosa and antagonist
12) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.55
To further analyze the mechanism by which KARs modulate the inhibitory transmission in SG neurons, we examined the effect of ATPA on miniature IPSCs (mIPSCs).
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
13) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.25
Consistently, we found that ATPA markedly increased the frequency of sIPSCs in all SG neurons tested in the presence of bicuculline or strychnine, suggesting that the activation of GluR5 facilitates both GABAergic and glycinergic transmission in the SG.


Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa and gabaergic
14) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.83
Both GABAergic and glycinergic release were enhanced by GluR5 activation in SG neurons
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa and gabaergic
15) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.70
Effect of ATPA on sIPSCs and firing patterns of spinal SG neurons
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
16) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.54
Activation of presynaptic GluR5 increases the frequency of mIPSCs in SG neurons
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
17) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.28
No difference in mIPSC frequency and amplitude in SG neurons between wild-type and GluR5-/- mice
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
18) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.09 Pain Relevance 0.25
We found that the activation of GluR5 by ATPA increased the frequency of sIPSCs in all SG neurons tested.
Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
19) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.38
Therefore, we wanted to know whether tonic activation of presynaptic GluR5 KARs modulates inhibitory synaptic transmission in SG neurons in the spinal cord.
Gene_expression (neurons) of SG in spinal cord associated with substantia gelatinosa and spinal cord
20) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.74

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