INT125447

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 4.71
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (CLDN4) plasma membrane (CLDN4)
Anatomy Link Frequency
pores 1
endometrium 1
CLDN4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 56 99.84 Very High Very High Very High
diclofenac 7 99.56 Very High Very High Very High
Crohn's disease 5 99.16 Very High Very High Very High
spastic colon 71 94.40 High High
Inflammation 9 90.08 High High
Bile 21 77.28 Quite High
cytokine 4 39.44 Quite Low
Pain 1 30.16 Quite Low
endometriosis 8 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 99.12 Very High Very High Very High
Disease 22 98.84 Very High Very High Very High
Alagille Syndrome 21 96.60 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

68 94.40 High High
Stomach Cancer 7 93.80 High High
Inflammatory Bowel Disease 72 91.48 High High
Apoptosis 7 85.88 High High
Recurrence 1 83.92 Quite High
Adhesions 8 73.44 Quite High
Leukemia 12 66.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these results, we consider that the induction of claudin-4 and other tight junction-related genes by NSAIDs may be involved in the chemopreventive effect of NSAIDs through the suppression of anchorage-independent growth and cell migration.
Positive_regulation (induction) of claudin-4 associated with cinod
1) Confidence 0.70 Published 2005 Journal Cancer Res. Section Abstract Doc Link 15753385 Disease Relevance 0.34 Pain Relevance 0.42
Furthermore, an intracellular Ca2+ chelator [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] inhibited the indomethacin-dependent induction of claudin-4.
Positive_regulation (induction) of claudin-4
2) Confidence 0.70 Published 2005 Journal Cancer Res. Section Abstract Doc Link 15753385 Disease Relevance 0.51 Pain Relevance 0.48
Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect.
Positive_regulation (Induction) of claudin-4 associated with inflammation and cinod
3) Confidence 0.70 Published 2005 Journal Cancer Res. Section Title Doc Link 15753385 Disease Relevance 0.36 Pain Relevance 0.55
Other drugs that increased the intracellular Ca2+ concentration (thapsigargin and ionomycin) also induced claudin-4.
Positive_regulation (induced) of claudin-4
4) Confidence 0.70 Published 2005 Journal Cancer Res. Section Abstract Doc Link 15753385 Disease Relevance 0.44 Pain Relevance 0.52
These results strongly suggest that induction of claudin-4 by indomethacin is mediated through an increase in the intracellular Ca2+ concentration.
Positive_regulation (induction) of claudin-4
5) Confidence 0.70 Published 2005 Journal Cancer Res. Section Abstract Doc Link 15753385 Disease Relevance 0.52 Pain Relevance 0.52
Induction of claudin-4 by indomethacin was confirmed at both mRNA and protein levels.
Positive_regulation (Induction) of claudin-4
6) Confidence 0.70 Published 2005 Journal Cancer Res. Section Abstract Doc Link 15753385 Disease Relevance 0.34 Pain Relevance 0.56
NSAIDs, other than indomethacin (diclofenac and celecoxib), also induced claudin-4.
Positive_regulation (induced) of claudin-4 associated with cinod and diclofenac
7) Confidence 0.70 Published 2005 Journal Cancer Res. Section Abstract Doc Link 15753385 Disease Relevance 0.44 Pain Relevance 0.56
Two studies proposed that CLDN4 and LIF are upregulated by the action of progesterone [23,24].
Positive_regulation (upregulated) of CLDN4
8) Confidence 0.68 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
Claudin-4 mRNA and protein show different patterns of expression during different cycle stages. cDNA microarray analysis of the midluteal phase endometrial transcriptome revealed increased CLDN4 mRNA, compared to other luteal phase stages (4–6).
Positive_regulation (increased) of CLDN4 mRNA
9) Confidence 0.68 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.21 Pain Relevance 0
A possible mechanism supporting the association of high CLDN4 expression with non-pregnancy could be an adverse concentration of chloride caused by an increase in CLDN4-containing pores.
Positive_regulation (increase) of CLDN4-containing in pores
10) Confidence 0.59 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
While the role of CLDN4 in the optimization of endometrium for implantation is not clear, our results suggest that higher levels of CLDN4 are associated with lower pregnancy and birth rates.
Positive_regulation (levels) of CLDN4 in endometrium
11) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
Faecal Clostridium counts were significantly increased during the follow-up period compared to the basal and scFOS periods (P < 0.05).
Positive_regulation (increased) of Clostridium
12) Confidence 0.30 Published 2007 Journal Nutr J Section Body Doc Link PMC2228298 Disease Relevance 0 Pain Relevance 0.04
The proportion of Clostridium clostridioforme was increased by both RS, and the increase reached statistical significance for RS4 (p<0.05).
Positive_regulation (increased) of Clostridium clostridioforme
13) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993935 Disease Relevance 0 Pain Relevance 0
A number of publications have reported a decrease of bacteria belonging to the groups Clostridium XIVa and Clostridium IV in patients with Crohn's disease (CD), [18-20].
Positive_regulation (groups) of Clostridium associated with crohn's disease and disease
14) Confidence 0.03 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC3002299 Disease Relevance 1.03 Pain Relevance 0.79

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