INT125448

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.01
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (CLDN4) plasma membrane (CLDN4)
Anatomy Link Frequency
AGS 2
CLDN4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 16 80.88 Quite High
diclofenac 2 78.28 Quite High
endometriosis 4 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alagille Syndrome 6 99.84 Very High Very High Very High
Apoptosis 2 97.56 Very High Very High Very High
INFLAMMATION 4 75.00 Quite High
Stomach Cancer 2 66.92 Quite High
Leukemia 6 50.00 Quite Low
Reprotox - General 3 14 5.00 Very Low Very Low Very Low
Male Infertility 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Polycystic Ovary Syndrome 4 5.00 Very Low Very Low Very Low
Endometriosis (extended) 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, addition of indomethacin or overexpression of claudin-4 inhibited cell migration.
Positive_regulation (overexpression) of Gene_expression (overexpression) of claudin-4
1) Confidence 0.70 Published 2005 Journal Cancer Res. Section Abstract Doc Link 15753385 Disease Relevance 0.47 Pain Relevance 0.46
Overexpression of claudin-4 in AGS cells did not affect cell growth or the induction of apoptosis by indomethacin.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of claudin-4 in AGS associated with alagille syndrome and apoptosis
2) Confidence 0.70 Published 2005 Journal Cancer Res. Section Abstract Doc Link 15753385 Disease Relevance 0.53 Pain Relevance 0.56
An increase of CLDN4 mRNA expression during the implantation window has been reported by several groups, and these findings support a functional role for this tight junction protein in implantation [4-6].
Positive_regulation (increase) of Gene_expression (expression) of CLDN4 mRNA
3) Confidence 0.68 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
Another study reported only weak endometrial CLDN4 expression in normal women during the secretory phase [11].
Positive_regulation (endometrial) of Gene_expression (expression) of CLDN4
4) Confidence 0.43 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0

General Comments

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