INT125449

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.07
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (CLDN4) plasma membrane (CLDN4)
Anatomy Link Frequency
AGS 2
CLDN4 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 6 91.84 High High
cINOD 8 80.88 Quite High
diclofenac 1 78.28 Quite High
analgesia 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alagille Syndrome 3 100.00 Very High Very High Very High
Apoptosis 1 98.68 Very High Very High Very High
Reprotox - General 3 21 96.88 Very High Very High Very High
Endometriosis (extended) 6 91.84 High High
Polycystic Ovary Syndrome 6 89.52 High High
Male Infertility 6 83.12 Quite High
INFLAMMATION 2 75.00 Quite High
Stomach Cancer 1 66.92 Quite High
Leukemia 9 50.00 Quite Low
Disease 3 44.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two cores of human prostate tissue were also included in the TMArrayer™ as positive controls for CLDN4 expression.
Regulation (controls) of Gene_expression (expression) of CLDN4
1) Confidence 0.60 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
Overexpression of claudin-4 in AGS cells did not affect cell growth or the induction of apoptosis by indomethacin.
Neg (not) Regulation (affect) of Gene_expression (Overexpression) of claudin-4 in AGS associated with alagille syndrome and apoptosis
2) Confidence 0.45 Published 2005 Journal Cancer Res. Section Abstract Doc Link 15753385 Disease Relevance 0.54 Pain Relevance 0.57
There was no association between CLDN4 expression and stage of luteal phase.


Neg (no) Regulation (association) of Gene_expression (expression) of CLDN4
3) Confidence 0.44 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.54 Pain Relevance 0.05
These data also re-emphasize the importance of LIF, as LIF+ immunolabeling is strongly associated with a higher chance of pregnancy, an outcome that is not affected by strong expression of CLDN4.
Neg (not) Regulation (affected) of Gene_expression (expression) of CLDN4
4) Confidence 0.44 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0

General Comments

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