INT12545

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.53
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
blood 1
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 3 97.64 Very High Very High Very High
tetrodotoxin 1 97.00 Very High Very High Very High
qutenza 4 91.28 High High
cINOD 3 82.20 Quite High
agonist 8 80.24 Quite High
adenocard 2 78.12 Quite High
peptic ulcer disease 1 75.92 Quite High
antagonist 5 74.48 Quite High
Pain 8 67.60 Quite High
Calcium channel 1 61.68 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 14 100.00 Very High Very High Very High
Ulcers 4 100.00 Very High Very High Very High
Injury 1 98.38 Very High Very High Very High
Cv General 3 Under Development 3 97.64 Very High Very High Very High
Duodenal Ulcer 6 92.96 High High
Necrosis 1 92.08 High High
INFLAMMATION 12 81.96 Quite High
Disease 1 75.92 Quite High
Pressure And Volume Under Development 2 68.76 Quite High
Pain 8 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The contribution of other products of the various pathways of arachidonic acid metabolism to gastric mucosal injury and the mechanism underlying the close interrelationship between protection and inhibition of LTC4 formation observed with certain compounds remains to be investigated.
Negative_regulation (inhibition) of LTC4 associated with injury
1) Confidence 0.42 Published 1991 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 1782414 Disease Relevance 0.33 Pain Relevance 0.14
Our results suggest that alpha-linolenic acid affectively suppressed the indomethacin-induced decreases in gastric mucosal blood flow by increasing EPA and decreasing the levels of arachidonic acid and LTC4 in the gastric mucosa.
Negative_regulation (decreasing) of LTC4 in blood
2) Confidence 0.37 Published 2003 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12878448 Disease Relevance 0 Pain Relevance 0
In 11 patients PAF, LTB4, and LTC4 generation was also assessed after 4 weeks of treatment resulting in ulcer healing and found to be significantly reduced when compared with their synthesis when the ulcer was active.
Negative_regulation (reduced) of LTC4 associated with ulcers
3) Confidence 0.18 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.85 Pain Relevance 0.08
Lower and higher doses of LTC4 (< 80 fmol and 8 pmol <) did not show the alteration of nocifensive behaviors by ??
Negative_regulation (doses) of LTC4
4) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.24 Pain Relevance 0.31
TXB2, LTC4 and peptideLTs levels on week after an attack of AMI significantly decreased compared with those at the acute stage, and these values decreased to normal control levels one month after an attack of AMI.
Negative_regulation (decreased) of LTC4 associated with myocardial infarction
5) Confidence 0.12 Published 1991 Journal Nippon Ika Daigaku Zasshi Section Abstract Doc Link 1906069 Disease Relevance 1.10 Pain Relevance 0.25
In separate experiments, responses to LTC4 were also reduced by approximately 50% if LTC4 conversion to LTD4 and LTE4 was first prevented by L-serine borate (45 mM) in combination with L-cysteine (10 mM).
Negative_regulation (reduced) of LTC4
6) Confidence 0.06 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8430808 Disease Relevance 0 Pain Relevance 0.10
ONO-1078 0.03 mg.kg-1, i.v. completely blocked the responses to LTC4, attenuated those to Cap, but had no effect to SP.
Negative_regulation (blocked) of LTC4
7) Confidence 0.03 Published 1996 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 9812736 Disease Relevance 0 Pain Relevance 0
In tissues pretreated with acivicin, which inhibits conversion of LTC4 to LTD4, the response to LTC4, but not LTD4, was abolished.
Negative_regulation (abolished) of LTC4
8) Confidence 0.02 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1649293 Disease Relevance 0 Pain Relevance 0.19

General Comments

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