INT125467

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2011
Negated 5
Speculated 5
Reported most in Body
Documents 35
Total Number 47
Disease Relevance 39.07
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
cytoplasm (CDKN2A) cytosol (CDKN2A) nucleolus (CDKN2A)
Anatomy Link Frequency
vulva 4
telomere 4
blood 2
cartilage 2
fibroblasts 2
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 634 99.80 Very High Very High Very High
narcan 2 99.70 Very High Very High Very High
Osteoarthritis 88 97.36 Very High Very High Very High
antagonist 1 96.92 Very High Very High Very High
cytokine 116 92.36 High High
rheumatoid arthritis 148 90.12 High High
Chronic pancreatitis 13 85.88 High High
metalloproteinase 34 85.36 High High
Inflammation 88 79.48 Quite High
Inflammatory response 5 77.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 1393 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 6 100.00 Very High Very High Very High
Acute Renal Failure 2 99.92 Very High Very High Very High
Apoptosis 203 99.06 Very High Very High Very High
Melanoma 642 99.02 Very High Very High Very High
Aging 733 98.80 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 568 98.68 Very High Very High Very High
Mouth Cancer 19 98.48 Very High Very High Very High
Pancreatic Cancer 75 97.88 Very High Very High Very High
Papillomavirus Infection 447 97.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of p16 in the carcinomatous regions of MMMT (Figure 1E) with inverse expression of p21 in these regions denotes an upregulation of p16.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p16 associated with cancer
1) Confidence 0.63 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.81 Pain Relevance 0
Overexpression of p16 is believed to be the result of mutated p16 gene product and/or an accumulation due to decreased turnover of the protein [2].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p16
2) Confidence 0.63 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.82 Pain Relevance 0
In our study cases 46.2% of subjects who survived 2 years had positive p16 overexpression in contrast to a lower expression in 10% of cases with less than two year survival.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p16
3) Confidence 0.63 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.97 Pain Relevance 0
In the present study we found that knockdown of CBX7 resulted in increased p16(INK4a) expression and was accompanied by decreased transformed phenotype and migration ability, which suggested regulation of p16(INK4a) might be one of the important mechanisms of CBX7 in gastric cancer.
Positive_regulation (resulted) of Gene_expression (expression) of INK4a associated with stomach cancer
4) Confidence 0.59 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.84 Pain Relevance 0
However, so far little has been found concerning the mechanism of enhanced expression of p14ARF and p16INK4A in the carcinogenesis of vulvar SCC.
Positive_regulation (enhanced) of Gene_expression (expression) of p14ARF associated with basal and squamous cell skin cancer
5) Confidence 0.55 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.42 Pain Relevance 0
Integration of the HPV DNA into the host genome leads to the development of a typical vulvar intraepithelial neoplasia (VIN), accompanied with overexpression of p14ARF and p16INK4A.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p16INK4A associated with papillomavirus infection and cancer
6) Confidence 0.55 Published 2011 Journal Journal of Skin Cancer Section Abstract Doc Link PMC3003991 Disease Relevance 2.02 Pain Relevance 0
In 2 out of 18 tumors negative for p16 protein expression, we were unable to detect any genetic alteration in the form of deletion, mutation or promoter hypermethylation.
Positive_regulation (negative) of Gene_expression (expression) of p16 associated with cancer
7) Confidence 0.50 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.10 Pain Relevance 0
This is similar to the increased expression of p16INK4a seen in osteoarticular cartilage [35] and suggests that p16INK4a may be physiologically involved in the senescence process, particularly as p16INK4a may accumulate in response to specific forms of stress, including oxidative damage [18].
Positive_regulation (increased) of Gene_expression (expression) of p16INK4a in cartilage associated with stress and aging
8) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.59 Pain Relevance 0
We have demonstrated that in non-degenerate discs p16INK4a increases with age but that degenerate discs show overexpression of p16INK4a compared to age-matched non-degenerate samples.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p16INK4a
9) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.58 Pain Relevance 0
In our analysis, the associations of MC1R variants with melanoma risk did not differ statistically significantly depending on whether CDKN2A mutations altered only the p16INK4a protein or both p16INK4a and p14ARF proteins.
Neg (not) Spec (whether) Positive_regulation (depending) of Gene_expression (protein) of p14ARF associated with melanocortin 1 receptor and melanoma
10) Confidence 0.49 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.55 Pain Relevance 1.04
For each continent, we checked whether the CDKN2A mutation carriers who were genotyped or not genotyped for MC1R differed in terms of melanoma affection status, sex, and age at examination and found that there was no difference (data not shown).
Neg (not) Spec (whether) Positive_regulation (genotyped) of Neg (not) Gene_expression (genotyped) of CDKN2A associated with melanocortin 1 receptor and melanoma
11) Confidence 0.49 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.51 Pain Relevance 0.36
In the present study we found that knockdown of CBX7 resulted in increased p16(INK4a) expression and was accompanied by decreased transformed phenotype and migration ability, which suggested regulation of p16(INK4a) might be one of the important mechanisms of CBX7 in gastric cancer.
Positive_regulation (increased) of Gene_expression (expression) of p16 associated with stomach cancer
12) Confidence 0.49 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.83 Pain Relevance 0
In our analysis, the associations of MC1R variants with melanoma risk did not differ statistically significantly depending on whether CDKN2A mutations altered only the p16INK4a protein or both p16INK4a and p14ARF proteins.
Neg (not) Spec (whether) Positive_regulation (depending) of Gene_expression (protein) of p16INK4a associated with melanocortin 1 receptor and melanoma
13) Confidence 0.49 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.55 Pain Relevance 1.04
In our analysis, the associations of MC1R variants with melanoma risk did not differ statistically significantly depending on whether CDKN2A mutations altered only the p16INK4a protein or both p16INK4a and p14ARF proteins.
Neg (not) Spec (whether) Positive_regulation (depending) of Gene_expression (protein) of p16INK4a associated with melanocortin 1 receptor and melanoma
14) Confidence 0.49 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.54 Pain Relevance 1.03
Many studies have investigated tumor-mediated molecular alterations of the pancreatic juice, as k-ras mutations, telomerase reactivation, or promoter methylation of the tumor-suppressor genes p16INK4a and p14ARF.
Spec (investigated) Positive_regulation (reactivation) of Spec (investigated) Gene_expression (mutations) of p16INK4a associated with cancer
15) Confidence 0.49 Published 2004 Journal Dig Dis Section Abstract Doc Link 15753605 Disease Relevance 0.79 Pain Relevance 0.09
IL-23 is composed of the IL-12p40 and a p19 subunit and likewise binds to a receptor with one of the IL-12 receptor subunits (IL-12R?
Positive_regulation (composed) of Gene_expression (subunit) of p19
16) Confidence 0.49 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.43 Pain Relevance 0.23
OGF treatment increased cyclin-dependent kinase inhibitor p16 protein expression.
Positive_regulation (increased) of Gene_expression (expression) of p16
17) Confidence 0.47 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974995 Disease Relevance 0.24 Pain Relevance 0.26
Blockade of OGF-OGFr interactions with naloxone abolished the increased expression of p16 protein by OGF.
Positive_regulation (increased) of Gene_expression (expression) of p16 associated with narcan
18) Confidence 0.47 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974995 Disease Relevance 0.21 Pain Relevance 0.25
In particular, we have found that telomeric erosion increases with age together with increased levels of p16INK4a.
Positive_regulation (increased) of Gene_expression (levels) of p16INK4a
19) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.80 Pain Relevance 0
Importantly, this study has shown that degenerate discs exhibit accelerated senescence with decreased telomere length, reduced cell replication potential, and elevated levels of p16INK4a and SA-?
Positive_regulation (elevated) of Gene_expression (levels) of p16INK4a in telomere associated with aging
20) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.79 Pain Relevance 0

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