INT125477

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 91
Total Number 96
Disease Relevance 31.18
Pain Relevance 12.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HHIP) plasma membrane (HHIP) carbohydrate metabolic process (HHIP)
cytoplasm (HHIP)
Anatomy Link Frequency
hip 35
HEK 4
vesicles 3
pancreas 3
knee 3
HHIP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4666 100.00 Very High Very High Very High
Anterior cingulate cortex 111 100.00 Very High Very High Very High
imagery 311 99.98 Very High Very High Very High
Osteoarthritis 626 99.16 Very High Very High Very High
Chronic pancreatitis 63 99.00 Very High Very High Very High
Pain 417 98.84 Very High Very High Very High
analgesia 13 98.72 Very High Very High Very High
depression 11 94.80 High High
Arthritis 53 93.20 High High
alcohol 22 87.48 High High
Disease Link Frequency Relevance Heat
Frailty 233 100.00 Very High Very High Very High
Hip Fractures 74 100.00 Very High Very High Very High
Pancreatic Cancer 45 99.86 Very High Very High Very High
Hip Fracture Prevention (HIT) 3 99.84 Very High Very High Very High
Coronary Artery Disease 132 99.80 Very High Very High Very High
Disease 254 99.60 Very High Very High Very High
Calcification 111 99.24 Very High Very High Very High
Knee Osteoarthritis 530 99.16 Very High Very High Very High
Increased Venous Pressure Under Development 67 99.16 Very High Very High Very High
Sprains And Strains 469 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study we analyzed the expression, distribution, and function of another component of this signaling pathway, the human hedgehog-interacting protein (Hip), in the normal pancreas, CP and PDAC utilizing real-time quantitative reverse transcription-polymerase chain reaction (QRT-PCR), immunohistochemistry, immunofluorescence, Hip siRNA transfection, cell growth assays, and cell cycle analysis.
Spec (analyzed) Gene_expression (expression) of Hip in pancreas associated with adenocarcinoma and chronic pancreatitis
1) Confidence 0.78 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 1.03 Pain Relevance 0.37
The different pattern of Hip expression and abnormal localization in the diseased pancreas suggest that the enhanced activation of hedgehog signaling in CP and PDAC is-at least in part-due to the aberrant responsiveness and expression of Hip in these diseases.
Gene_expression (expression) of Hip in Hip associated with adenocarcinoma, disease and chronic pancreatitis
2) Confidence 0.78 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 1.18 Pain Relevance 0.32
In addition, silencing of Hip expression using specific siRNA molecules increased the growth of SU-8686 cells.
Gene_expression (expression) of Hip in Hip
3) Confidence 0.78 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 1.03 Pain Relevance 0.31
As shown by immunohistochemistry, Hip was expressed in normal pancreatic tissues mainly in the cytoplasm of islet cells and in smooth muscle cells of blood vessels.
Gene_expression (expressed) of Hip in blood vessels
4) Confidence 0.78 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 1.33 Pain Relevance 0.37
Only SU-8686 and BxPC-3 pancreatic cancer cells expressed Hip mRNA, whereas expression was below the level of detection in the other six pancreatic cancer cell lines tested.
Gene_expression (expressed) of Hip mRNA in Hip associated with pancreatic cancer
5) Confidence 0.78 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 1.30 Pain Relevance 0.39
In conclusion, Hip is expressed in the normal pancreas, CP and PDAC tissues.
Gene_expression (expressed) of Hip in Hip associated with adenocarcinoma and chronic pancreatitis
6) Confidence 0.78 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 1.01 Pain Relevance 0.32
The different pattern of Hip expression and abnormal localization in the diseased pancreas suggest that the enhanced activation of hedgehog signaling in CP and PDAC is-at least in part-due to the aberrant responsiveness and expression of Hip in these diseases.
Gene_expression (expression) of Hip in Hip associated with adenocarcinoma, disease and chronic pancreatitis
7) Confidence 0.68 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 0.96 Pain Relevance 0.26
In the current study we analyzed the expression, distribution, and function of another component of this signaling pathway, the human hedgehog-interacting protein (Hip), in the normal pancreas, CP and PDAC utilizing real-time quantitative reverse transcription-polymerase chain reaction (QRT-PCR), immunohistochemistry, immunofluorescence, Hip siRNA transfection, cell growth assays, and cell cycle analysis.
Spec (analyzed) Gene_expression (expression) of hedgehog-interacting protein in pancreas associated with adenocarcinoma and chronic pancreatitis
8) Confidence 0.67 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 1.03 Pain Relevance 0.37
In the current study we analyzed the expression, distribution, and function of another component of this signaling pathway, the human hedgehog-interacting protein (Hip), in the normal pancreas, CP and PDAC utilizing real-time quantitative reverse transcription-polymerase chain reaction (QRT-PCR), immunohistochemistry, immunofluorescence, Hip siRNA transfection, cell growth assays, and cell cycle analysis.
Gene_expression (transfection) of Hip in pancreas associated with adenocarcinoma and chronic pancreatitis
9) Confidence 0.60 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 1.08 Pain Relevance 0.36
A handheld dynamometer (HHD) (Nicholas MMT, Lafayette Instruments, Lafayette, IN) will be placed 5 cm proximal to the lateral and medial femoral condyles for the hip abduction and adduction trials, respectively.
Gene_expression (abduction) of hip in condyles
10) Confidence 0.59 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2235855 Disease Relevance 0 Pain Relevance 0
The hip muscles, particularly the abductors, play an important role in stablization of the pelvis and trunk.
Gene_expression (muscles) of hip in trunk
11) Confidence 0.59 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2235855 Disease Relevance 0.63 Pain Relevance 0.32
However, little attention has been paid to improving the strength of other lower limb muscle groups such as the hip abductors and adductors.
Gene_expression (abductors) of hip in limb muscle
12) Confidence 0.59 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2235855 Disease Relevance 0.66 Pain Relevance 0.26
To ensure that strength gains are limited to the hip abductors and adductors, measurement of hip flexion, extension, rotation (both internal and external), and knee extension will also be conducted.
Gene_expression (abductors) of hip in internal
13) Confidence 0.59 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2235855 Disease Relevance 0.56 Pain Relevance 0.24
Less is known about the hip adductor muscles in relation to knee OA but they may also help reduce the knee adduction moment, particularly in a varus malaligned knee.
Gene_expression (adductor muscles) of hip in knee associated with osteoarthritis
14) Confidence 0.59 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2235855 Disease Relevance 0.45 Pain Relevance 0.23
Participants will undergo isometric strength assessment of hip abduction, adduction, extension, flexion, internal rotation and external rotation as well as knee extension.
Gene_expression (abduction) of hip in external
15) Confidence 0.59 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2235855 Disease Relevance 0.16 Pain Relevance 0.08
Hip strengthening group
Gene_expression (group) of Hip in Hip
16) Confidence 0.59 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2235855 Disease Relevance 0.35 Pain Relevance 0.27
Participants will perform a series of 6 exercises designed to strengthen the hip abductor and adductor muscles (Table 1) at home, five times per week for 12 weeks.
Gene_expression (abductor) of hip in adductor muscles
17) Confidence 0.59 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2235855 Disease Relevance 0.29 Pain Relevance 0.23
The effects of hip muscle strengthening on knee load, pain, and function in people with knee osteoarthritis: a protocol for a randomised, single-blind controlled trial

Background

Gene_expression (muscle) of hip in knee associated with pain, knee osteoarthritis and osteoarthritis
18) Confidence 0.59 Published 2007 Journal BMC Musculoskelet Disord Section Title Doc Link PMC2235855 Disease Relevance 0.75 Pain Relevance 0.50
Possible involvement of the ACC and Hip activities in generating the P300
Gene_expression (activities) of Hip in Hip associated with anterior cingulate cortex
19) Confidence 0.57 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2607283 Disease Relevance 0.07 Pain Relevance 0.19
CONCLUSION: A better recognition of "prefracture" pain in the elderly may allow adequate management and treatment of patients, in order to avoid a proportion of hip fractures.


Gene_expression (fractures) of hip in hip
20) Confidence 0.56 Published 2008 Journal Clin. Exp. Rheumatol. Section Body Doc Link 18578971 Disease Relevance 0 Pain Relevance 0

General Comments

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