INT125479

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 38
Total Number 40
Disease Relevance 12.39
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HHIP) plasma membrane (HHIP) carbohydrate metabolic process (HHIP)
cytoplasm (HHIP)
Anatomy Link Frequency
hip 20
spine 2
spinal 1
tail 1
vesicles 1
HHIP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1711 99.98 Very High Very High Very High
Chronic pancreatitis 14 99.84 Very High Very High Very High
imagery 117 99.56 Very High Very High Very High
Pain 75 96.92 Very High Very High Very High
backache 23 91.52 High High
Electroencephalography 9 85.60 High High
Anterior cingulate cortex 37 80.52 Quite High
Hippocampus 3 62.00 Quite High
Potency 32 45.56 Quite Low
Dopamine 16 44.40 Quite Low
Disease Link Frequency Relevance Heat
Frailty 330 100.00 Very High Very High Very High
Hip Fractures 148 100.00 Very High Very High Very High
Pancreatitis 14 99.84 Very High Very High Very High
Hypercalcemia 180 99.80 Very High Very High Very High
Disease 148 99.60 Very High Very High Very High
Osteoarthritis 32 99.32 Very High Very High Very High
Adenocarcinoma 16 99.20 Very High Very High Very High
Growth Problems 5 98.76 Very High Very High Very High
Stroke 89 98.16 Very High Very High Very High
Body Weight 9 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By QRT-PCR, Hip mRNA levels were fifteenfold and fourteenfold increased in CP (n = 22) and PDAC (n = 31) tissues, respectively, compared to normal pancreatic tissues (n=20) and correlated with glioma associated antigen (Gli1) but not Ptc or Protein kinase A (PKA) mRNA levels.
Positive_regulation (increased) of Hip mRNA in Hip associated with adenocarcinoma, chronic pancreatitis and glioma
1) Confidence 0.44 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 1.21 Pain Relevance 0.41
PATIENTS AND METHODS: For a period of 6 months, each subject (>65 years) treated for hip fracture was prospectively recruited in an orthopaedic surgery department.
Positive_regulation (treated) of hip in hip
2) Confidence 0.42 Published 2008 Journal Clin. Exp. Rheumatol. Section Body Doc Link 18578971 Disease Relevance 0.09 Pain Relevance 0
The different pattern of Hip expression and abnormal localization in the diseased pancreas suggest that the enhanced activation of hedgehog signaling in CP and PDAC is-at least in part-due to the aberrant responsiveness and expression of Hip in these diseases.
Positive_regulation (responsiveness) of Hip in Hip associated with adenocarcinoma, disease and chronic pancreatitis
3) Confidence 0.41 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15754313 Disease Relevance 0.96 Pain Relevance 0.26
We also progress patients to weight bearing as tolerated without the use of an assistive device, and place patients on progressive resistive exercises to improve hip abductor and extensor strength as long as resistive exercise does not cause pain.
Positive_regulation (improve) of hip in hip associated with pain
4) Confidence 0.39 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2857827 Disease Relevance 0.25 Pain Relevance 0.25
We present the case of a 68-year-old man who underwent bilateral metal-on-metal hip resurfacing for osteoarthrosis.
Positive_regulation (underwent) of hip in hip associated with osteoarthritis
5) Confidence 0.37 Published 2009 Journal Br J Radiol Section Abstract Doc Link 19386954 Disease Relevance 0.51 Pain Relevance 0.09
Activation in the Hip has usually been studied under oddball paradigms as will be described below, and reports describing Hip activity in response to simple sensory stimuli are rare.
Positive_regulation (Activation) of Hip in Hip
6) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2607283 Disease Relevance 0 Pain Relevance 0.29
It has been suggested that the torque force applied to the femoral neck while the patient is turning may be enough to induce a hip fracture.
Positive_regulation (induce) of hip in hip associated with frailty
7) Confidence 0.16 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998805 Disease Relevance 1.61 Pain Relevance 0.18
Observational studies in men with idiopathic and secondary osteoporosis suggest that intermittent cyclical etidronate therapy (Didronel PMO) increases BMD at the lumbar spine by 5%–10%, with smaller increases at the hip.
Positive_regulation (increases) of hip in hip associated with osteoporosis
8) Confidence 0.15 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686344 Disease Relevance 0.44 Pain Relevance 0
A subsequent analysis of the HORIZON-RFT when the time interval between fracture repair surgery and administration of zoledronic acid was taken into account revealed that administration of zoledronic acid two weeks or more after surgical repair of the fracture was associated with significant reductions in clinical vertebral, nonvertebral, and hip fractures, as well as increased hip BMD.31 Results of this study point to the possibility of administering zoledronic acid to patients hospitalized for hip or other osteoporotic fractures while still in hospital,32 thus significantly improving compliance and outcome.


Positive_regulation (increased) of hip in hip associated with osteoporotic fractures and hip fractures
9) Confidence 0.11 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998805 Disease Relevance 0.60 Pain Relevance 0
Significant increases in hip BMD were also noted in women receiving zoledronic acid compared with placebo.
Positive_regulation (increases) of hip in hip
10) Confidence 0.11 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998805 Disease Relevance 0.33 Pain Relevance 0
In men and women the risk of hip fractures is also increased by conditions predisposing to falls, such as strokes, Parkinsonism, dementia, vertigo, alcoholism and visual impairment (Grisso et al 1991; Poor et al 1995).


Positive_regulation (increased) of hip in hip associated with parkinson's disease, alcohol addiction, dementia, vertigo, stroke and hip fractures
11) Confidence 0.11 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686344 Disease Relevance 1.28 Pain Relevance 0
Interim analysis at one year showed a significant increase in lumbar spine and total hip BMD with clodronate compared with placebo, with similar changes in men and women.
Positive_regulation (increase) of hip in hip
12) Confidence 0.11 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686344 Disease Relevance 0.31 Pain Relevance 0
It increases BMD at the lumbar spine and hip by 14.4 and 8.3% respectively after three years, although at least half of this increase is the result of the incorporation of metal into bone rather than its effect on bone mineralization (Meunier et al 2004).
Positive_regulation (increases) of hip in hip
13) Confidence 0.10 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686344 Disease Relevance 0.82 Pain Relevance 0.08
Protein, calcium, and vitamin D supplementation is associated with increased hip BMD and a reduction in falls.
Positive_regulation (increased) of hip in hip
14) Confidence 0.07 Published 2010 Journal Osteoporos Int Section Abstract Doc Link PMC2974929 Disease Relevance 0.91 Pain Relevance 0
These data suggest that agonist-dependent activation of the hIP leads to direct time-dependent activation of Rab5 leading to its net translocation from the cytosolic/soluble fraction leading to its activation.
Positive_regulation (activation) of hIP associated with agonist
15) Confidence 0.06 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.29
These data suggest that agonist-activation of the hIP may directly couple to Rab5, promoting the release of GDI and, in turn, stimulating membrane association and GDP/GTP exchange to regulate hIP trafficking from the cell surface to Rab5-positive endosomes.
Positive_regulation (activation) of hIP associated with agonist
16) Confidence 0.06 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.16
Furthermore, cicaprost-stimulation caused a further increase in hIP: Rab5aQ79L association (Fig. 5, upper panel).
Positive_regulation (increase) of hIP in upper
17) Confidence 0.06 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.27
Analysis also showed that for both hip and non-vertebral fractures, the anti-fracture efficacy increased significantly with a higher received dose (metaregression: ß?
Positive_regulation (increased) of hip in hip
18) Confidence 0.05 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2974929 Disease Relevance 0.35 Pain Relevance 0
By 4 h post-agonist stimulation, the hIP, hIP?
Positive_regulation (stimulation) of hIP associated with agonist
19) Confidence 0.05 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.12
Hence, in view of our findings herein involving Rab5, we sought to determine whether expression of DynK44A alone or DynK44A along with Rab5aS34N might affect the overall level of cicaprost-induced hIP internalization.
Positive_regulation (induced) of hIP
20) Confidence 0.05 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0

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