INT125520

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PLAT, GDF15) extracellular region (PLAT, GDF15) signal transduction (GDF15)
peptidase activity (PLAT) protein modification process (PLAT) cell-cell signaling (GDF15)
PLAT (Homo sapiens)
GDF15 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 8 98.96 Very High Very High Very High
Inflammation 4 58.80 Quite High
cINOD 2 53.48 Quite High
cytokine 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 4 97.92 Very High Very High Very High
Prostate Cancer 4 75.00 Quite High
INFLAMMATION 4 58.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that NAG-1 expression is up-regulated by TPA in LNCaP cells through a PKC-dependent pathway involving the activation of NF-kappa B.
TPA Positive_regulation (up-regulated) of Gene_expression (expression) of NAG-1 associated with kinase c
1) Confidence 0.13 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.33 Pain Relevance 0.18
Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival.
TPA Positive_regulation (induced) of Gene_expression (expression) of NAG-1 associated with apoptosis
2) Confidence 0.12 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.41 Pain Relevance 0.24

General Comments

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