INT125523

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.33
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PLAT, GDF15) extracellular region (PLAT, GDF15) signal transduction (GDF15)
peptidase activity (PLAT) protein modification process (PLAT) cell-cell signaling (GDF15)
PLAT (Homo sapiens)
GDF15 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 12 99.52 Very High Very High Very High
Inflammation 6 90.48 High High
cINOD 3 85.16 High High
cytokine 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Prostate Cancer 6 97.32 Very High Very High Very High
Apoptosis 6 90.92 High High
INFLAMMATION 6 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.
TPA Positive_regulation (increase) of NAG-1 protein associated with kinase c
1) Confidence 0.13 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.45 Pain Relevance 0.25
Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.
TPA Positive_regulation (induced) of NAG-1 associated with kinase c
2) Confidence 0.12 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.44 Pain Relevance 0.24
TPA treatment increased NAG-1 protein and mRNA levels in a time- and concentration-dependent manner as well as NF-kappa B binding/transcriptional activity in LNCaP cells.
TPA Positive_regulation (increased) of NAG-1 protein
3) Confidence 0.12 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.44 Pain Relevance 0.26

General Comments

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