INT125524

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKDC) protein modification process (PRKDC) nucleus (PRKDC)
enzyme binding (PRKDC) DNA binding (PRKDC) transcription factor binding (PRKDC)
Anatomy Link Frequency
brain 2
PRKDC (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 4 90.04 High High
Inflammation 2 72.12 Quite High
cINOD 1 66.80 Quite High
Limbic system 4 54.64 Quite High
cytokine 2 25.00 Low Low
amygdala 58 5.00 Very Low Very Low Very Low
nMDA receptor 25 5.00 Very Low Very Low Very Low
Glutamate 21 5.00 Very Low Very Low Very Low
long-term potentiation 14 5.00 Very Low Very Low Very Low
withdrawal 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 21 99.24 Very High Very High Very High
Prostate Cancer 2 78.96 Quite High
Apoptosis 3 72.56 Quite High
INFLAMMATION 2 72.12 Quite High
Autism 314 62.28 Quite High
Cognitive Disorder 43 58.12 Quite High
Anxiety Disorder 52 5.00 Very Low Very Low Very Low
Intellectual Impairment 24 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 11 5.00 Very Low Very Low Very Low
Phobia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of constitutively active PKCs induced an increase in NF-kappa B transcriptional activity and NAG-1 protein levels in LNCaP cells.
Positive_regulation (induced) of Gene_expression (Expression) of PKCs
1) Confidence 0.09 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.44 Pain Relevance 0.26
In the brain, this common molecular syndrome is proposed to have a dual effect of causing hyper-reactivity and hyper-plasticity of microcircuits to produce hyper-functionality (Figure 5).
Positive_regulation (causing) of Gene_expression (produce) of hyper-functionality in brain associated with syndrome
2) Confidence 0.01 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.56 Pain Relevance 0.03

General Comments

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